Clinical implications of serum levels of soluble CD30 in 70 adult anaplastic large-cell lymphoma patients

Pier Luigi Zinzani, Stefano Pileri, Maurizio Bendandi, Marina Buzzi, Elena Sabattini, Stefano Ascani, Filippo Gherlinzoni, Massimo Magagnoli, Patrizia Albertini, Sante Tura

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: In the last few years, the search for new biologic markers in high-grade non-Hodgkin's lymphomas has provided important results. In particular, soluble CD30 (sCD30) levels were elevated in most patients with Hodgkin's disease (HD) and anaplastic large-cell lymphoma (ALCL). Patients and Methods: From September 1988 to October 1993, treatment was completed in 70 previously untreated patients with ALCL, of whom 38 had the common type (ALCL-CT) and 32 had the Hodgkin's-like subtype (ALCL-HL). Serum sCD30 levels were measured at the time of diagnosis and after induction polychemotherapy in all patients; in addition, the initial sCD30 levels were compared with those obtained from 50 stage-matched patients with HD. Results: Pretreatment levels of sCD30 were highly elevated in the stage-matched group of HD patients compared with healthy controls; median sCD30 levels in patients with ALCL-CT and ALCL-HL were 18 and seven times higher, respectively, than in patients with HD. The sCD30 level normalized on achievement of complete response (CR). The risk of lower relapse-free survival was associated with bulky disease, advanced stage, and high pretreatment sCD30 levels; the risk of lower overall survival was associated with advanced stage and pretreatment levels of sCD30 in both univariate and multivariate analysis. Conclusion: The results of this study suggest that sCD30 is a specific prognostic indicator of the risk for lower complete response rate and relapse-free expectancy for patients with ALCL.

Original languageEnglish
Pages (from-to)1532-1537
Number of pages6
JournalJournal of Clinical Oncology
Volume16
Issue number4
Publication statusPublished - Apr 1998

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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