Clinical implications, safety, efficacy of recombinant human granulocyte colony-stimulating factors and pegylated equivalent

Silvia Bolis, Emilia Cocorocchio, Consuelo Corti, Andrés J M Ferreri, Niccolò Frungillo, Giovanni Grillo, Emanuela Salè Omodeo, Lucilla Tedeschi, Vittorio Ruggero Zilioli

Research output: Contribution to journalArticle

Abstract

A wide use of recombinant human granulocyte colony-stimulating factors (G-CSFs) and their pegylated equivalent is a significant step forward in the treatment of both solid tumors and hematological malignancies. Evidence-based use of these molecules resulted in more intensive treatments, safely extended to frail and elderly patients, and development of response- and comorbidity-tailored approaches. The available G-CSFs are filgrastim, and the long-acting pegfilgrastim, which are produced in E. Coli cells, and are chemically different from native human G-CSF, and lenograstim, a molecule produced in mammalian cells, with a chemical structure identical to native human G-CSF. These chemical differences produce a diverse interaction with receptors and stimulated neutrophils. For instance, lenograstim binds to receptors in the same way of endogenous ligand, and neutrophils obtained from stimulation with this G-CSF have a physiological activity profile similar to neutrophils normally generated in humans. Conversely, the different interaction between filgrastim and G-CSF receptor is more frequently associated with morphological abnormalities, reduced motility and chemotaxis and a reduced response to bacterial stimuli in induced neutrophils. On this background, we reviewed available evidence in order to analyze the impact of these chemical and pharmacodynamic differences among G-CSF molecules on safety, particularly in healthy peripheral-blood stem-cells donors, functional qualities of inducted neutrophils, and mobilization of hematopoietic stem cells.

Original languageEnglish
Article numbere8845
JournalEpidemiology Biostatistics and Public Health
Volume10
Issue number4
DOIs
Publication statusPublished - 2013

Keywords

  • Autologous stem cells transplantation
  • Filgrastim
  • Granulocytes-colony stimulating factors
  • Lenograstim
  • Neutrophils
  • Pegfilgrastim
  • Stem cells mobilization

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Community and Home Care

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