Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome

Ulrike Benninghoff; Federica Cattaneo; Alessandro Aiuti; Alberto Flores-D'Arcais; Carlo Gelmetti; Matteo Viscardi; Luciano Callegaro; Massimiliano Mirolo; Alessandro Ambrosi; Maria Grazia Roncarolo; Rosa Bacchetta

doi:10.1111/j.1399-3038.2007.00683.x

Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome

Ulrike Benninghoff, Federica Cattaneo, Alessandro Aiuti, Alberto Flores-D'Arcais, Carlo Gelmetti, Matteo Viscardi, Luciano Callegaro, Massimiliano Mirolo, Alessandro Ambrosi, Maria Grazia Roncarolo, Rosa Bacchetta

Research output: Contribution to journal › Article › peer-review

Abstract

We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.

Original language	English
Pages (from-to)	564-568
Number of pages	5
Journal	Pediatric Allergy and Immunology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1111/j.1399-3038.2007.00683.x
Publication status	Published - Sep 2008

Keywords

Cytokines
Eczema
Hyper-IgE syndrome
Immunodeficiency
Interferon-α

ASJC Scopus subject areas

Immunology and Allergy
Pediatrics, Perinatology, and Child Health
Immunology

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Benninghoff, U., Cattaneo, F., Aiuti, A., Flores-D'Arcais, A., Gelmetti, C., Viscardi, M., Callegaro, L., Mirolo, M., Ambrosi, A., Roncarolo, M. G., & Bacchetta, R. (2008). Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome. Pediatric Allergy and Immunology, 19(6), 564-568. https://doi.org/10.1111/j.1399-3038.2007.00683.x

Benninghoff, U, Cattaneo, F, Aiuti, A, Flores-D'Arcais, A, Gelmetti, C, Viscardi, M, Callegaro, L, Mirolo, M, Ambrosi, A, Roncarolo, MG & Bacchetta, R 2008, 'Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome', Pediatric Allergy and Immunology, vol. 19, no. 6, pp. 564-568. https://doi.org/10.1111/j.1399-3038.2007.00683.x

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AU - Flores-D'Arcais, Alberto

AU - Gelmetti, Carlo

AU - Viscardi, Matteo

AU - Callegaro, Luciano

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Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome

Abstract

Keywords

ASJC Scopus subject areas

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