TY - JOUR
T1 - Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome
AU - Benninghoff, Ulrike
AU - Cattaneo, Federica
AU - Aiuti, Alessandro
AU - Flores-D'Arcais, Alberto
AU - Gelmetti, Carlo
AU - Viscardi, Matteo
AU - Callegaro, Luciano
AU - Mirolo, Massimiliano
AU - Ambrosi, Alessandro
AU - Roncarolo, Maria Grazia
AU - Bacchetta, Rosa
PY - 2008/9
Y1 - 2008/9
N2 - We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.
AB - We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.
KW - Cytokines
KW - Eczema
KW - Hyper-IgE syndrome
KW - Immunodeficiency
KW - Interferon-α
UR - http://www.scopus.com/inward/record.url?scp=49749112063&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49749112063&partnerID=8YFLogxK
U2 - 10.1111/j.1399-3038.2007.00683.x
DO - 10.1111/j.1399-3038.2007.00683.x
M3 - Article
C2 - 18844858
AN - SCOPUS:49749112063
VL - 19
SP - 564
EP - 568
JO - Pediatric Allergy and Immunology
JF - Pediatric Allergy and Immunology
SN - 0905-6157
IS - 6
ER -