Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome

Ulrike Benninghoff; Federica Cattaneo; Alessandro Aiuti; Alberto Flores-D'Arcais; Carlo Gelmetti; Matteo Viscardi; Luciano Callegaro; Massimiliano Mirolo; Alessandro Ambrosi; Maria Grazia Roncarolo; Rosa Bacchetta

doi:10.1111/j.1399-3038.2007.00683.x

Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome

Ulrike Benninghoff, Federica Cattaneo, Alessandro Aiuti, Alberto Flores-D'Arcais, Carlo Gelmetti, Matteo Viscardi, Luciano Callegaro, Massimiliano Mirolo, Alessandro Ambrosi, Maria Grazia Roncarolo, Rosa Bacchetta

Research output: Contribution to journal › Article › peer-review

Abstract

We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.

Original language	English
Pages (from-to)	564-568
Number of pages	5
Journal	Pediatric Allergy and Immunology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1111/j.1399-3038.2007.00683.x
Publication status	Published - Sep 2008

Keywords

Cytokines
Eczema
Hyper-IgE syndrome
Immunodeficiency
Interferon-α

ASJC Scopus subject areas

Immunology and Allergy
Pediatrics, Perinatology, and Child Health
Immunology

Access to Document

10.1111/j.1399-3038.2007.00683.x

Cite this

Benninghoff, U., Cattaneo, F., Aiuti, A., Flores-D'Arcais, A., Gelmetti, C., Viscardi, M., Callegaro, L., Mirolo, M., Ambrosi, A., Roncarolo, M. G., & Bacchetta, R. (2008). Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome. Pediatric Allergy and Immunology, 19(6), 564-568. https://doi.org/10.1111/j.1399-3038.2007.00683.x

Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome. / Benninghoff, Ulrike; Cattaneo, Federica; Aiuti, Alessandro; Flores-D'Arcais, Alberto; Gelmetti, Carlo; Viscardi, Matteo; Callegaro, Luciano; Mirolo, Massimiliano; Ambrosi, Alessandro; Roncarolo, Maria Grazia; Bacchetta, Rosa.

In: Pediatric Allergy and Immunology, Vol. 19, No. 6, 09.2008, p. 564-568.

Research output: Contribution to journal › Article › peer-review

Benninghoff, U, Cattaneo, F, Aiuti, A, Flores-D'Arcais, A, Gelmetti, C, Viscardi, M, Callegaro, L, Mirolo, M, Ambrosi, A, Roncarolo, MG & Bacchetta, R 2008, 'Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome', Pediatric Allergy and Immunology, vol. 19, no. 6, pp. 564-568. https://doi.org/10.1111/j.1399-3038.2007.00683.x

Benninghoff, Ulrike ; Cattaneo, Federica ; Aiuti, Alessandro ; Flores-D'Arcais, Alberto ; Gelmetti, Carlo ; Viscardi, Matteo ; Callegaro, Luciano ; Mirolo, Massimiliano ; Ambrosi, Alessandro ; Roncarolo, Maria Grazia ; Bacchetta, Rosa. / Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome. In: Pediatric Allergy and Immunology. 2008 ; Vol. 19, No. 6. pp. 564-568.

@article{2b87cfee60e04b02a5d82bf2b2471356,

title = "Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome",

abstract = "We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.",

keywords = "Cytokines, Eczema, Hyper-IgE syndrome, Immunodeficiency, Interferon-α",

author = "Ulrike Benninghoff and Federica Cattaneo and Alessandro Aiuti and Alberto Flores-D'Arcais and Carlo Gelmetti and Matteo Viscardi and Luciano Callegaro and Massimiliano Mirolo and Alessandro Ambrosi and Roncarolo, {Maria Grazia} and Rosa Bacchetta",

year = "2008",

month = sep,

doi = "10.1111/j.1399-3038.2007.00683.x",

language = "English",

volume = "19",

pages = "564--568",

journal = "Pediatric Allergy and Immunology",

issn = "0905-6157",

publisher = "Blackwell Munksgaard",

number = "6",

}

TY - JOUR

T1 - Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome

AU - Benninghoff, Ulrike

AU - Cattaneo, Federica

AU - Aiuti, Alessandro

AU - Flores-D'Arcais, Alberto

AU - Gelmetti, Carlo

AU - Viscardi, Matteo

AU - Callegaro, Luciano

AU - Mirolo, Massimiliano

AU - Ambrosi, Alessandro

AU - Roncarolo, Maria Grazia

AU - Bacchetta, Rosa

PY - 2008/9

Y1 - 2008/9

N2 - We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.

AB - We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.

KW - Cytokines

KW - Eczema

KW - Hyper-IgE syndrome

KW - Immunodeficiency

KW - Interferon-α

UR - http://www.scopus.com/inward/record.url?scp=49749112063&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49749112063&partnerID=8YFLogxK

U2 - 10.1111/j.1399-3038.2007.00683.x

DO - 10.1111/j.1399-3038.2007.00683.x

M3 - Article

C2 - 18844858

AN - SCOPUS:49749112063

VL - 19

SP - 564

EP - 568

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

SN - 0905-6157

IS - 6

ER -

Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this