Abstract
Objectives: We compared the clinical, laboratory, and radiological features of different subgroups of acute transverse myelitis (ATM) diagnosed according to the criteria established by the Transverse Myelitis Consortium Working Group (TMCWG) as well as of non-inflammatory acute transverse myelopathies (NIATM) to identify possible short- and long-term prognostic factors. Methods: A multicenter and retrospective study comprising 110 patients with ATM and 15 NIATM admitted to five Italian neurological units between January 2010 and December 2014 was carried out. Results: A significantly higher frequency of isolated sensory disturbances at onset in ATM than in NIATM patients (chi-square = 14. 7; P = 0.005) and a significantly higher frequency of motor symptoms in NIATM than ATM (chi-square = 12.4; P = 0.014) was found. ATM patients with high disability at discharge had more motor-sensory symptoms without (OR = 3.87; P = 0.04) and with sphincter dysfunction at onset (OR = 7.4; P = 0.0009) compared to those with low disability. Higher age (OR = 1.08; P = 0.001) and motor-sensory-sphincter involvement at onset (OR = 9.52; P = 0.002) were significantly associated with a high disability score at discharge and after a median 1-year follow-up. Conclusions: The diagnosis of ATM may prevail respect to that of NIATM when a sensory symptomatology at onset occurs. In ATM, patients older and with motor-sensory involvement with or without sphincter impairment at admission could experience a major risk of poor prognosis both at discharge and at longer time requiring a timely and more appropriate treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 1383-1391 |
| Number of pages | 9 |
| Journal | Neurological Sciences |
| Volume | 40 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2019 |
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Keywords
- Connective autoimmune disorders
- Disability
- Multiple sclerosis
- Neuromyelitis optica spectrum disorders
- Prognosis
- Transverse myelitis
ASJC Scopus subject areas
- Dermatology
- Clinical Neurology
- Psychiatry and Mental health
Cite this
Clinical, laboratory features, and prognostic factors in adult acute transverse myelitis : an Italian multicenter study. / Annunziata, Pasquale; Masi, Gianni; Cioni, Chiara; Gastaldi, Matteo; Marchioni, Enrico; D’amico, Emanuele; Patti, Francesco; Laroni, Alice; Mancardi, Gianluigi; Vitetta, Francesca; Sola, Patrizia.
In: Neurological Sciences, Vol. 40, No. 7, 01.07.2019, p. 1383-1391.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical, laboratory features, and prognostic factors in adult acute transverse myelitis
T2 - an Italian multicenter study
AU - Annunziata, Pasquale
AU - Masi, Gianni
AU - Cioni, Chiara
AU - Gastaldi, Matteo
AU - Marchioni, Enrico
AU - D’amico, Emanuele
AU - Patti, Francesco
AU - Laroni, Alice
AU - Mancardi, Gianluigi
AU - Vitetta, Francesca
AU - Sola, Patrizia
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Objectives: We compared the clinical, laboratory, and radiological features of different subgroups of acute transverse myelitis (ATM) diagnosed according to the criteria established by the Transverse Myelitis Consortium Working Group (TMCWG) as well as of non-inflammatory acute transverse myelopathies (NIATM) to identify possible short- and long-term prognostic factors. Methods: A multicenter and retrospective study comprising 110 patients with ATM and 15 NIATM admitted to five Italian neurological units between January 2010 and December 2014 was carried out. Results: A significantly higher frequency of isolated sensory disturbances at onset in ATM than in NIATM patients (chi-square = 14. 7; P = 0.005) and a significantly higher frequency of motor symptoms in NIATM than ATM (chi-square = 12.4; P = 0.014) was found. ATM patients with high disability at discharge had more motor-sensory symptoms without (OR = 3.87; P = 0.04) and with sphincter dysfunction at onset (OR = 7.4; P = 0.0009) compared to those with low disability. Higher age (OR = 1.08; P = 0.001) and motor-sensory-sphincter involvement at onset (OR = 9.52; P = 0.002) were significantly associated with a high disability score at discharge and after a median 1-year follow-up. Conclusions: The diagnosis of ATM may prevail respect to that of NIATM when a sensory symptomatology at onset occurs. In ATM, patients older and with motor-sensory involvement with or without sphincter impairment at admission could experience a major risk of poor prognosis both at discharge and at longer time requiring a timely and more appropriate treatment.
AB - Objectives: We compared the clinical, laboratory, and radiological features of different subgroups of acute transverse myelitis (ATM) diagnosed according to the criteria established by the Transverse Myelitis Consortium Working Group (TMCWG) as well as of non-inflammatory acute transverse myelopathies (NIATM) to identify possible short- and long-term prognostic factors. Methods: A multicenter and retrospective study comprising 110 patients with ATM and 15 NIATM admitted to five Italian neurological units between January 2010 and December 2014 was carried out. Results: A significantly higher frequency of isolated sensory disturbances at onset in ATM than in NIATM patients (chi-square = 14. 7; P = 0.005) and a significantly higher frequency of motor symptoms in NIATM than ATM (chi-square = 12.4; P = 0.014) was found. ATM patients with high disability at discharge had more motor-sensory symptoms without (OR = 3.87; P = 0.04) and with sphincter dysfunction at onset (OR = 7.4; P = 0.0009) compared to those with low disability. Higher age (OR = 1.08; P = 0.001) and motor-sensory-sphincter involvement at onset (OR = 9.52; P = 0.002) were significantly associated with a high disability score at discharge and after a median 1-year follow-up. Conclusions: The diagnosis of ATM may prevail respect to that of NIATM when a sensory symptomatology at onset occurs. In ATM, patients older and with motor-sensory involvement with or without sphincter impairment at admission could experience a major risk of poor prognosis both at discharge and at longer time requiring a timely and more appropriate treatment.
KW - Connective autoimmune disorders
KW - Disability
KW - Multiple sclerosis
KW - Neuromyelitis optica spectrum disorders
KW - Prognosis
KW - Transverse myelitis
UR - http://www.scopus.com/inward/record.url?scp=85064060929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064060929&partnerID=8YFLogxK
U2 - 10.1007/s10072-019-03830-6
DO - 10.1007/s10072-019-03830-6
M3 - Article
AN - SCOPUS:85064060929
VL - 40
SP - 1383
EP - 1391
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 7
ER -