Clinical Laboratory Manifestations of Exposure to Dioxin in Children

A Six-Year Study of the Effects of an Environmental Disaster Near Seveso, Italy

Paolo Mocarelli, Alessandro Marocchi, Paolo Brambilla, Piermario Gerthoux, Donald S. Young, Nathan Mantel

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Following a major environmental accident near Seveso, Italy, on July 10, 1976, we attempted to determine if the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) released into the atmosphere had any effect on the liver function and lipid metabolism of exposed children. From July 1976 to June 1982, we analyzed the results of more than 4500 laboratory tests (alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, cholesterol, and triglycerides in plasma and δ-aminolevulinic acid in urine) in a population of about 1500 children aged 6 to 10 years at the moment of the accident. The children exposed to the highest concentration of TCDD showed alterations in serum γ-glutamyltransferase and alanine aminotransferase activity compared with the control group. These differences were restricted to values inside limits set from the lower end of the normal range to slightly above it. The observed abnormalities were slight and disappeared with time.

Original languageEnglish
Pages (from-to)2687-2695
Number of pages9
JournalJournal of the American Medical Association
Volume256
Issue number19
DOIs
Publication statusPublished - Nov 21 1986

Fingerprint

Dioxins
Disasters
Italy
Alanine Transaminase
Accidents
Aminolevulinic Acid
Aspartate Aminotransferases
Atmosphere
Lipid Metabolism
Alkaline Phosphatase
Reference Values
Triglycerides
Cholesterol
Urine
Control Groups
Liver
Serum
Population
Polychlorinated Dibenzodioxins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clinical Laboratory Manifestations of Exposure to Dioxin in Children : A Six-Year Study of the Effects of an Environmental Disaster Near Seveso, Italy. / Mocarelli, Paolo; Marocchi, Alessandro; Brambilla, Paolo; Gerthoux, Piermario; Young, Donald S.; Mantel, Nathan.

In: Journal of the American Medical Association, Vol. 256, No. 19, 21.11.1986, p. 2687-2695.

Research output: Contribution to journalArticle

Mocarelli, Paolo ; Marocchi, Alessandro ; Brambilla, Paolo ; Gerthoux, Piermario ; Young, Donald S. ; Mantel, Nathan. / Clinical Laboratory Manifestations of Exposure to Dioxin in Children : A Six-Year Study of the Effects of an Environmental Disaster Near Seveso, Italy. In: Journal of the American Medical Association. 1986 ; Vol. 256, No. 19. pp. 2687-2695.
@article{f1462647c07c420f8805d382d54bc2f9,
title = "Clinical Laboratory Manifestations of Exposure to Dioxin in Children: A Six-Year Study of the Effects of an Environmental Disaster Near Seveso, Italy",
abstract = "Following a major environmental accident near Seveso, Italy, on July 10, 1976, we attempted to determine if the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) released into the atmosphere had any effect on the liver function and lipid metabolism of exposed children. From July 1976 to June 1982, we analyzed the results of more than 4500 laboratory tests (alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, cholesterol, and triglycerides in plasma and δ-aminolevulinic acid in urine) in a population of about 1500 children aged 6 to 10 years at the moment of the accident. The children exposed to the highest concentration of TCDD showed alterations in serum γ-glutamyltransferase and alanine aminotransferase activity compared with the control group. These differences were restricted to values inside limits set from the lower end of the normal range to slightly above it. The observed abnormalities were slight and disappeared with time.",
author = "Paolo Mocarelli and Alessandro Marocchi and Paolo Brambilla and Piermario Gerthoux and Young, {Donald S.} and Nathan Mantel",
year = "1986",
month = "11",
day = "21",
doi = "10.1001/jama.1986.03380190057025",
language = "English",
volume = "256",
pages = "2687--2695",
journal = "JAMA - Journal of the American Medical Association",
issn = "0002-9955",
publisher = "American Medical Association",
number = "19",

}

TY - JOUR

T1 - Clinical Laboratory Manifestations of Exposure to Dioxin in Children

T2 - A Six-Year Study of the Effects of an Environmental Disaster Near Seveso, Italy

AU - Mocarelli, Paolo

AU - Marocchi, Alessandro

AU - Brambilla, Paolo

AU - Gerthoux, Piermario

AU - Young, Donald S.

AU - Mantel, Nathan

PY - 1986/11/21

Y1 - 1986/11/21

N2 - Following a major environmental accident near Seveso, Italy, on July 10, 1976, we attempted to determine if the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) released into the atmosphere had any effect on the liver function and lipid metabolism of exposed children. From July 1976 to June 1982, we analyzed the results of more than 4500 laboratory tests (alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, cholesterol, and triglycerides in plasma and δ-aminolevulinic acid in urine) in a population of about 1500 children aged 6 to 10 years at the moment of the accident. The children exposed to the highest concentration of TCDD showed alterations in serum γ-glutamyltransferase and alanine aminotransferase activity compared with the control group. These differences were restricted to values inside limits set from the lower end of the normal range to slightly above it. The observed abnormalities were slight and disappeared with time.

AB - Following a major environmental accident near Seveso, Italy, on July 10, 1976, we attempted to determine if the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) released into the atmosphere had any effect on the liver function and lipid metabolism of exposed children. From July 1976 to June 1982, we analyzed the results of more than 4500 laboratory tests (alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, cholesterol, and triglycerides in plasma and δ-aminolevulinic acid in urine) in a population of about 1500 children aged 6 to 10 years at the moment of the accident. The children exposed to the highest concentration of TCDD showed alterations in serum γ-glutamyltransferase and alanine aminotransferase activity compared with the control group. These differences were restricted to values inside limits set from the lower end of the normal range to slightly above it. The observed abnormalities were slight and disappeared with time.

UR - http://www.scopus.com/inward/record.url?scp=84944285696&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944285696&partnerID=8YFLogxK

U2 - 10.1001/jama.1986.03380190057025

DO - 10.1001/jama.1986.03380190057025

M3 - Article

VL - 256

SP - 2687

EP - 2695

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

SN - 0002-9955

IS - 19

ER -