Abstract
Following a major environmental accident near Seveso, Italy, on July 10, 1976, we attempted to determine if the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) released into the atmosphere had any effect on the liver function and lipid metabolism of exposed children. From July 1976 to June 1982, we analyzed the results of more than 4500 laboratory tests (alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, cholesterol, and triglycerides in plasma and δ-aminolevulinic acid in urine) in a population of about 1500 children aged 6 to 10 years at the moment of the accident. The children exposed to the highest concentration of TCDD showed alterations in serum γ-glutamyltransferase and alanine aminotransferase activity compared with the control group. These differences were restricted to values inside limits set from the lower end of the normal range to slightly above it. The observed abnormalities were slight and disappeared with time.
| Original language | English |
|---|---|
| Pages (from-to) | 2687-2695 |
| Number of pages | 9 |
| Journal | Journal of the American Medical Association |
| Volume | 256 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - Nov 21 1986 |
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ASJC Scopus subject areas
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Clinical Laboratory Manifestations of Exposure to Dioxin in Children : A Six-Year Study of the Effects of an Environmental Disaster Near Seveso, Italy. / Mocarelli, Paolo; Marocchi, Alessandro; Brambilla, Paolo; Gerthoux, Piermario; Young, Donald S.; Mantel, Nathan.
In: Journal of the American Medical Association, Vol. 256, No. 19, 21.11.1986, p. 2687-2695.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical Laboratory Manifestations of Exposure to Dioxin in Children
T2 - A Six-Year Study of the Effects of an Environmental Disaster Near Seveso, Italy
AU - Mocarelli, Paolo
AU - Marocchi, Alessandro
AU - Brambilla, Paolo
AU - Gerthoux, Piermario
AU - Young, Donald S.
AU - Mantel, Nathan
PY - 1986/11/21
Y1 - 1986/11/21
N2 - Following a major environmental accident near Seveso, Italy, on July 10, 1976, we attempted to determine if the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) released into the atmosphere had any effect on the liver function and lipid metabolism of exposed children. From July 1976 to June 1982, we analyzed the results of more than 4500 laboratory tests (alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, cholesterol, and triglycerides in plasma and δ-aminolevulinic acid in urine) in a population of about 1500 children aged 6 to 10 years at the moment of the accident. The children exposed to the highest concentration of TCDD showed alterations in serum γ-glutamyltransferase and alanine aminotransferase activity compared with the control group. These differences were restricted to values inside limits set from the lower end of the normal range to slightly above it. The observed abnormalities were slight and disappeared with time.
AB - Following a major environmental accident near Seveso, Italy, on July 10, 1976, we attempted to determine if the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) released into the atmosphere had any effect on the liver function and lipid metabolism of exposed children. From July 1976 to June 1982, we analyzed the results of more than 4500 laboratory tests (alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, cholesterol, and triglycerides in plasma and δ-aminolevulinic acid in urine) in a population of about 1500 children aged 6 to 10 years at the moment of the accident. The children exposed to the highest concentration of TCDD showed alterations in serum γ-glutamyltransferase and alanine aminotransferase activity compared with the control group. These differences were restricted to values inside limits set from the lower end of the normal range to slightly above it. The observed abnormalities were slight and disappeared with time.
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U2 - 10.1001/jama.1986.03380190057025
DO - 10.1001/jama.1986.03380190057025
M3 - Article
VL - 256
SP - 2687
EP - 2695
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0002-9955
IS - 19
ER -