Clinical manifestations in 28 Italian and Iranian patients with severe factor VII deficiency

F. Peyvandi, P. M. Mannucci, D. Asti, M. Abdoullahi, N. Di Rocco, R. Sharifian

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

There has been wide variation in the reported haemorrhagic manifestations of factor VII deficiency. We examined type and frequency of clinical manifestations in 28 Iranian and Italian patients with severe deficiency (factor VII coagulant activity 2% or less). The most frequent symptoms were epistaxis and menorrhagia, whereas soft tissue bleeding such as haemarthrosis acid muscle haematoma was less frequent. Only 5 of 9 patient who underwent surgery without factor VII replacement therapy had postoperative bleeding severe enough to require blood transfusion. No thrombotic manifestation occurred. A factor VII functional assay based on the use of human thromboplastin was a better predictor of the bleeding tendency of these patients than a rabbit thromboplastin-based functional assay or immunoassay. On the whole, this study shows that in severe factor VII deficiency bleeding in mucosal tracts is not uncommon. Surgery can sometimes be performed without replacement therapy and without haemorrhagic complications.

Original languageEnglish
Pages (from-to)242-246
Number of pages5
JournalHaemophilia
Volume3
Issue number4
Publication statusPublished - 1997

Fingerprint

Factor VII Deficiency
Hemorrhage
Factor VII
Thromboplastin
Hemarthrosis
Menorrhagia
Epistaxis
Immunoassay
Blood Transfusion
Hematoma
Rabbits
Muscles
Acids
Therapeutics

Keywords

  • Congenital bleeding disorders
  • Factor VII
  • Factor VII deficiency

ASJC Scopus subject areas

  • Hematology

Cite this

Clinical manifestations in 28 Italian and Iranian patients with severe factor VII deficiency. / Peyvandi, F.; Mannucci, P. M.; Asti, D.; Abdoullahi, M.; Di Rocco, N.; Sharifian, R.

In: Haemophilia, Vol. 3, No. 4, 1997, p. 242-246.

Research output: Contribution to journalArticle

Peyvandi, F, Mannucci, PM, Asti, D, Abdoullahi, M, Di Rocco, N & Sharifian, R 1997, 'Clinical manifestations in 28 Italian and Iranian patients with severe factor VII deficiency', Haemophilia, vol. 3, no. 4, pp. 242-246.
Peyvandi, F. ; Mannucci, P. M. ; Asti, D. ; Abdoullahi, M. ; Di Rocco, N. ; Sharifian, R. / Clinical manifestations in 28 Italian and Iranian patients with severe factor VII deficiency. In: Haemophilia. 1997 ; Vol. 3, No. 4. pp. 242-246.
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