Clinical manifestations of Behçet's disease in 137 Italian patients: Results of a multicenter study

Nicolò Pipitone, Luigi Boiardi, Ignazio Olivieri, Fabrizio Cantini, Fabrizio Salvi, Renato Malatesta, Renato La Corte, Giovanni Triolo, Angelo Ferrante, Davide Filippini, Giuseppe Paolazzi, Piercarlo Sarzi-Puttini, Giovanna Restuccia, Carlo Salvarani

Research output: Contribution to journalArticlepeer-review


Objective. To determine the type and frequency of clinical features of Behçet's disease in a population of Italian patients. Methods. We retrospectively studied 137 Italian patients (76 males and 61 females, age at onset 29.6 ± 12.2 [mean ± SD] years) seen consecutively in nine different referral centers. The duration of follow-up at study entry was 10.9 ± 8.2 years. Virtually all patients fulfilled the classification criteria developed by the International Study Group for Behçet's disease. The clinical manifestations of the patients were recorded by the attending physicians using specifically designed forms. Results. The most frequent manifestations at disease onset were oral (78.3%) and genital aphthae (29.2%) followed by inflammatory ocular involvement (20%) and arthritis (14.2%). The commonest (>50% of cases) manifestations observed throughout the disease course were oral aphthae (99.3%), genital aphthae (62.8%), various cutaneous lesions including erythema nodosum (81.8%), and inflammatory ocular disease (60.6%). Panuveitis and posterior uveitis/retinitis occurred more frequently in males compared with females (28.9% versus 11.5% and 57.9% versus 36.1%, respectively; p

Original languageEnglish
JournalClinical and Experimental Rheumatology
Issue number6 SUPPL.
Publication statusPublished - 2004


  • Behçet syndrome
  • Italy
  • Signs and symptoms

ASJC Scopus subject areas

  • Rheumatology
  • Immunology


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