TY - JOUR
T1 - Clinical manifestations of chronic atrophic gastritis
AU - Rodriguez-Castro, Kryssia Isabel
AU - Franceschi, Marilisa
AU - Noto, Antonino
AU - Miraglia, Chiara
AU - Nouvenne, Antonio
AU - Leandro, Gioacchino
AU - Meschi, Tiziana
AU - De’ Angelis, Gian Luigi
AU - Mario, Francesco Di
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Although the actual prevalence of chronic atrophic gastritis is unknown and it is probable that this entity goes largely underdiagnosed, patients in whom diagnosis is established usually present advanced stages of disease. Destruction of parietal cells, either autoimmune-driven or as a consequence of Helicobacter pylori infection, determines reduction or abolition of acid secretion. Hypo/achloridia causes an increase in serum gastrin levels, with an increased risk of the development of neuroendocrine tumors. Microcytic, hypochromic anemia frequently precedes the development of megaloblastic, vitamin B12-associated anemia. Moreover, vitamin B12 deficiency,may cause elevation of homocysteine, with an increase in the cardiovascular risk, and may be associated with neurological manifestations, mainly characterized by spinal cord demyelination and atrophy, with ensuing sensory-motor abnormalities. Gastrointestinal manifestations seem to be associated with non-acid reflux and tend to be non-specific. (www.actabiomedica.it).
AB - Although the actual prevalence of chronic atrophic gastritis is unknown and it is probable that this entity goes largely underdiagnosed, patients in whom diagnosis is established usually present advanced stages of disease. Destruction of parietal cells, either autoimmune-driven or as a consequence of Helicobacter pylori infection, determines reduction or abolition of acid secretion. Hypo/achloridia causes an increase in serum gastrin levels, with an increased risk of the development of neuroendocrine tumors. Microcytic, hypochromic anemia frequently precedes the development of megaloblastic, vitamin B12-associated anemia. Moreover, vitamin B12 deficiency,may cause elevation of homocysteine, with an increase in the cardiovascular risk, and may be associated with neurological manifestations, mainly characterized by spinal cord demyelination and atrophy, with ensuing sensory-motor abnormalities. Gastrointestinal manifestations seem to be associated with non-acid reflux and tend to be non-specific. (www.actabiomedica.it).
KW - Gastritis
KW - Megaloblastic
KW - Neuropathy
KW - Pernicious anemia
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U2 - 10.23750/abm.v89i8-S.7921
DO - 10.23750/abm.v89i8-S.7921
M3 - Review article
C2 - 30561424
AN - SCOPUS:85058762079
VL - 89
SP - 88
EP - 92
JO - Acta Biomedica de l'Ateneo Parmense
JF - Acta Biomedica de l'Ateneo Parmense
SN - 0392-4203
ER -