Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics

Kalyanam Shivkumar, Olujimi A. Ajijola, Inder Anand, J. A. Armour, Peng Sheng Chen, Murray D. Esler, Gaetano De Ferrari, Michael C. Fishbein, Jeffrey J. Goldberger, Ronald M. Harper, Michael J. Joyner, Sahib S. Khalsa, Rajesh Kumar, Richard D. Lane, Aman Mahajan, Sunny Po, Peter John Schwartz, Virend K. Somers, Miguel Valderrabano, Marmar Vaseghi & 1 others Douglas P. Zipes

Research output: Contribution to journalArticle

Abstract

Abstract: The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience-based cardiovascular therapeutics is increasingly evident. This White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology, pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.

Original languageEnglish
Pages (from-to)3911-3954
Number of pages44
JournalJournal of Physiology
Volume594
Issue number14
DOIs
Publication statusPublished - Jul 15 2016

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Neurosciences
Cardiovascular Diseases
Autonomic Nervous System Diseases
Neuroanatomy
Neurophysiology
Autonomic Nervous System
Therapeutics

ASJC Scopus subject areas

  • Physiology

Cite this

Shivkumar, K., Ajijola, O. A., Anand, I., Armour, J. A., Chen, P. S., Esler, M. D., ... Zipes, D. P. (2016). Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics. Journal of Physiology, 594(14), 3911-3954. https://doi.org/10.1113/JP271870

Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics. / Shivkumar, Kalyanam; Ajijola, Olujimi A.; Anand, Inder; Armour, J. A.; Chen, Peng Sheng; Esler, Murray D.; De Ferrari, Gaetano; Fishbein, Michael C.; Goldberger, Jeffrey J.; Harper, Ronald M.; Joyner, Michael J.; Khalsa, Sahib S.; Kumar, Rajesh; Lane, Richard D.; Mahajan, Aman; Po, Sunny; Schwartz, Peter John; Somers, Virend K.; Valderrabano, Miguel; Vaseghi, Marmar; Zipes, Douglas P.

In: Journal of Physiology, Vol. 594, No. 14, 15.07.2016, p. 3911-3954.

Research output: Contribution to journalArticle

Shivkumar, K, Ajijola, OA, Anand, I, Armour, JA, Chen, PS, Esler, MD, De Ferrari, G, Fishbein, MC, Goldberger, JJ, Harper, RM, Joyner, MJ, Khalsa, SS, Kumar, R, Lane, RD, Mahajan, A, Po, S, Schwartz, PJ, Somers, VK, Valderrabano, M, Vaseghi, M & Zipes, DP 2016, 'Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics', Journal of Physiology, vol. 594, no. 14, pp. 3911-3954. https://doi.org/10.1113/JP271870
Shivkumar K, Ajijola OA, Anand I, Armour JA, Chen PS, Esler MD et al. Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics. Journal of Physiology. 2016 Jul 15;594(14):3911-3954. https://doi.org/10.1113/JP271870
Shivkumar, Kalyanam ; Ajijola, Olujimi A. ; Anand, Inder ; Armour, J. A. ; Chen, Peng Sheng ; Esler, Murray D. ; De Ferrari, Gaetano ; Fishbein, Michael C. ; Goldberger, Jeffrey J. ; Harper, Ronald M. ; Joyner, Michael J. ; Khalsa, Sahib S. ; Kumar, Rajesh ; Lane, Richard D. ; Mahajan, Aman ; Po, Sunny ; Schwartz, Peter John ; Somers, Virend K. ; Valderrabano, Miguel ; Vaseghi, Marmar ; Zipes, Douglas P. / Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics. In: Journal of Physiology. 2016 ; Vol. 594, No. 14. pp. 3911-3954.
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