Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics

Kalyanam Shivkumar, Olujimi A. Ajijola, Inder Anand, J. A. Armour, Peng Sheng Chen, Murray D. Esler, Gaetano De Ferrari, Michael C. Fishbein, Jeffrey J. Goldberger, Ronald M. Harper, Michael J. Joyner, Sahib S. Khalsa, Rajesh Kumar, Richard D. Lane, Aman Mahajan, Sunny Po, Peter John Schwartz, Virend K. Somers, Miguel Valderrabano, Marmar VaseghiDouglas P. Zipes

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Abstract

Abstract: The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience-based cardiovascular therapeutics is increasingly evident. This White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology, pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.

Original languageEnglish
Pages (from-to)3911-3954
Number of pages44
JournalJournal of Physiology
Volume594
Issue number14
DOIs
Publication statusPublished - Jul 15 2016

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ASJC Scopus subject areas

  • Physiology

Cite this

Shivkumar, K., Ajijola, O. A., Anand, I., Armour, J. A., Chen, P. S., Esler, M. D., De Ferrari, G., Fishbein, M. C., Goldberger, J. J., Harper, R. M., Joyner, M. J., Khalsa, S. S., Kumar, R., Lane, R. D., Mahajan, A., Po, S., Schwartz, P. J., Somers, V. K., Valderrabano, M., ... Zipes, D. P. (2016). Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics. Journal of Physiology, 594(14), 3911-3954. https://doi.org/10.1113/JP271870