Studio clinico, neurofisiologico e neuroradiologico di un'ampia casistica di soggetti con polimicrogiria perisilviania

Translated title of the contribution: Clinical, neurophisiological and neuroradiologic findings in patients with perysilvian polymicrogyria

R. Borgatti, P. Piccinelli, C. Zucca, F. Triulzi, A. Tofani, L. Radice, C. Baldoli, U. Balottin

Research output: Contribution to journalArticlepeer-review

Abstract

Perisylvian polymicrogyria (PP) is a dysfunction in cortical development with a varying degree of abnormal cortical organization. It may unilaterally or bilaterally involve the opercular and perisylvian regions, as well as the parietal and superior temporal regions. We have described 20 patients with neurologic dysfunction and mental retardation of varying severity. Epilepsy was present in 60% of the patients and usually emerged between six and 10 years of age. Seizures were drug-resistant in only one patient, with the remaining patients either well (33.3%) or partially controlled (58.4%). A pseudobulbar palsy was present in 95% of the patients, while a cognitive deficit of variable severity was found in 80% of the subjects. This study indicates that the clinical and epileptic spectrum of this syndrome is broad but that a PP must be suspected in all the patients with mild or severe mental retardation and with diplegia of facial, pharyngeal and masticatory muscles.

Translated title of the contributionClinical, neurophisiological and neuroradiologic findings in patients with perysilvian polymicrogyria
Original languageItalian
Pages (from-to)43-51
Number of pages9
JournalSAGGI - Neuropsicologia Infantile Psicopedagogia Riabilitazione
Volume25
Issue number1
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neuroscience(all)
  • Psychology(all)

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