Clinical Operational Tolerance After Solid Organ Transplantation

P. Di Cocco, L. Bonanni, M. D'Angelo, K. Clemente, S. Greco, V. Rizza, C. Mazzotta, C. Scelzo, A. Famulari, F. Pisani, G. Orlando

Research output: Contribution to journalArticlepeer-review


Clinical operational tolerance (COT) is a clinical condition obtainable with difficulty after solid organ transplantation (SOT). It is characterized by perfectly normal graft function in the total absence of maintenance immunosuppression. Major benefits deriving from the onset of COT are the reduction of risk for immunosuppression-related side effects and the improved quality of life. Currently, COT can be safely achieved in stable liver transplant recipients; it remains a challenge after renal transplantation. Only 1 case of COT has been reported after lung transplantation; no cases have been described after other types of SOT. Overall, mechanisms of COT are unclear and strategies to induce COT cannot be applied on a regular base to a large cohort of SOT recipients. Due to the failure of molecularly based tolerogenic protocols, great hope relies in the adoption of cell-based strategies.

Original languageEnglish
Pages (from-to)1278-1282
Number of pages5
JournalTransplantation Proceedings
Issue number4
Publication statusPublished - May 2009

ASJC Scopus subject areas

  • Surgery
  • Transplantation
  • Medicine(all)


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