Clinical outcome after 4 years follow-up of HIV-seropositive subjects with incomplete virologic or immunologic response to HAART

Emanuele Nicastri, Antonio Chiesi, Claudio Angeletti, Loredana Sarmati, Lucia Palmisano, Andrea Geraci, Massimo Andreoni, Stefano Vella

Research output: Contribution to journalArticlepeer-review

Abstract

The duration of the clinical, virologic, and immunologic response to HAART, is not well defined. In this observational multi-center study 2,143 patients were enrolled classified according to virologic suppression (100 CD4+ cells/μl from baseline) at month 12 of HAART as complete responders, virologic only responders, immunologic only responders and non-responders. Kaplan Meyer curves, multivariate and politomous regression analysis were used. Complete responders patients were 781 (36.4%), immunologic only responders 441 (20.6%), virologic only responders 336 (15.7%), and non-responders 585 (27.3%). Using multivariate analysis, being antiretroviral-naïve increased the probability of having both a virologic only or a complete response and reduced the probability of an immunologic only response (P

Original languageEnglish
Pages (from-to)153-160
Number of pages8
JournalJournal of Medical Virology
Volume76
Issue number2
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Clinical progression
  • Discordant response
  • HAART
  • HIV infection

ASJC Scopus subject areas

  • Virology

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