TY - JOUR
T1 - Clinical outcome after 4 years follow-up of HIV-seropositive subjects with incomplete virologic or immunologic response to HAART
AU - Nicastri, Emanuele
AU - Chiesi, Antonio
AU - Angeletti, Claudio
AU - Sarmati, Loredana
AU - Palmisano, Lucia
AU - Geraci, Andrea
AU - Andreoni, Massimo
AU - Vella, Stefano
PY - 2005/6
Y1 - 2005/6
N2 - The duration of the clinical, virologic, and immunologic response to HAART, is not well defined. In this observational multi-center study 2,143 patients were enrolled classified according to virologic suppression (100 CD4+ cells/μl from baseline) at month 12 of HAART as complete responders, virologic only responders, immunologic only responders and non-responders. Kaplan Meyer curves, multivariate and politomous regression analysis were used. Complete responders patients were 781 (36.4%), immunologic only responders 441 (20.6%), virologic only responders 336 (15.7%), and non-responders 585 (27.3%). Using multivariate analysis, being antiretroviral-naïve increased the probability of having both a virologic only or a complete response and reduced the probability of an immunologic only response (P
AB - The duration of the clinical, virologic, and immunologic response to HAART, is not well defined. In this observational multi-center study 2,143 patients were enrolled classified according to virologic suppression (100 CD4+ cells/μl from baseline) at month 12 of HAART as complete responders, virologic only responders, immunologic only responders and non-responders. Kaplan Meyer curves, multivariate and politomous regression analysis were used. Complete responders patients were 781 (36.4%), immunologic only responders 441 (20.6%), virologic only responders 336 (15.7%), and non-responders 585 (27.3%). Using multivariate analysis, being antiretroviral-naïve increased the probability of having both a virologic only or a complete response and reduced the probability of an immunologic only response (P
KW - Clinical progression
KW - Discordant response
KW - HAART
KW - HIV infection
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U2 - 10.1002/jmv.20352
DO - 10.1002/jmv.20352
M3 - Article
C2 - 15834865
AN - SCOPUS:17844373522
VL - 76
SP - 153
EP - 160
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 2
ER -