Clinical outcome and survival after esophagectomy for carcinoma in elderly patients

Luigi Bonavina, R. Incarbone, G. Saino, P. Clesi, A. Peracchia

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Advances in perioperative management have allowed more and more elderly patients to undergo major surgery with postoperative morbidity and mortality rates comparable to those of younger individuals. The aim of this study was to evaluate the impact of age on the clinical outcome and long-term survival of patients with esophageal carcinoma undergoing esophagectomy. Nine-hundred patients with esophageal carcinoma were divided into two groups: A (n = 403) with age ≥ 65 years, and B (n = 497) with age <65 years. One-hundred and fifty three (38%) patients of group A underwent surgery compared to 272 (55%) of group B (P <0.01). Postoperative mortality, and the prevalence of anastomotic leak and respiratory complications were similar in both groups; conversely, there was a higher prevalence of cardiovascular complications in group A (13% vs 3%, P <0.01). Five-year survival was about 35% in both groups. In conclusion, advanced age should no longer be considered an absolute contraindication to esophagectomy for carcinoma in-selected patients. In fact, the postoperative mortality and long-term survival rates of elderly patients undergoing resection are comparable to that of younger individuals.

Original languageEnglish
Pages (from-to)90-93
Number of pages4
JournalDiseases of the Esophagus
Volume16
Issue number2
DOIs
Publication statusPublished - 2003

Fingerprint

Esophagectomy
Carcinoma
Survival
Mortality
Anastomotic Leak
Survival Rate
Morbidity

Keywords

  • Carcinoma
  • Elderly age
  • Esophagus
  • Postoperative complications

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Clinical outcome and survival after esophagectomy for carcinoma in elderly patients. / Bonavina, Luigi; Incarbone, R.; Saino, G.; Clesi, P.; Peracchia, A.

In: Diseases of the Esophagus, Vol. 16, No. 2, 2003, p. 90-93.

Research output: Contribution to journalArticle

Bonavina, Luigi ; Incarbone, R. ; Saino, G. ; Clesi, P. ; Peracchia, A. / Clinical outcome and survival after esophagectomy for carcinoma in elderly patients. In: Diseases of the Esophagus. 2003 ; Vol. 16, No. 2. pp. 90-93.
@article{f472f90d6f5846499418eaa44a31b57a,
title = "Clinical outcome and survival after esophagectomy for carcinoma in elderly patients",
abstract = "Advances in perioperative management have allowed more and more elderly patients to undergo major surgery with postoperative morbidity and mortality rates comparable to those of younger individuals. The aim of this study was to evaluate the impact of age on the clinical outcome and long-term survival of patients with esophageal carcinoma undergoing esophagectomy. Nine-hundred patients with esophageal carcinoma were divided into two groups: A (n = 403) with age ≥ 65 years, and B (n = 497) with age <65 years. One-hundred and fifty three (38{\%}) patients of group A underwent surgery compared to 272 (55{\%}) of group B (P <0.01). Postoperative mortality, and the prevalence of anastomotic leak and respiratory complications were similar in both groups; conversely, there was a higher prevalence of cardiovascular complications in group A (13{\%} vs 3{\%}, P <0.01). Five-year survival was about 35{\%} in both groups. In conclusion, advanced age should no longer be considered an absolute contraindication to esophagectomy for carcinoma in-selected patients. In fact, the postoperative mortality and long-term survival rates of elderly patients undergoing resection are comparable to that of younger individuals.",
keywords = "Carcinoma, Elderly age, Esophagus, Postoperative complications",
author = "Luigi Bonavina and R. Incarbone and G. Saino and P. Clesi and A. Peracchia",
year = "2003",
doi = "10.1046/j.1442-2050.2003.00300.x",
language = "English",
volume = "16",
pages = "90--93",
journal = "Diseases of the Esophagus",
issn = "1120-8694",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Clinical outcome and survival after esophagectomy for carcinoma in elderly patients

AU - Bonavina, Luigi

AU - Incarbone, R.

AU - Saino, G.

AU - Clesi, P.

AU - Peracchia, A.

PY - 2003

Y1 - 2003

N2 - Advances in perioperative management have allowed more and more elderly patients to undergo major surgery with postoperative morbidity and mortality rates comparable to those of younger individuals. The aim of this study was to evaluate the impact of age on the clinical outcome and long-term survival of patients with esophageal carcinoma undergoing esophagectomy. Nine-hundred patients with esophageal carcinoma were divided into two groups: A (n = 403) with age ≥ 65 years, and B (n = 497) with age <65 years. One-hundred and fifty three (38%) patients of group A underwent surgery compared to 272 (55%) of group B (P <0.01). Postoperative mortality, and the prevalence of anastomotic leak and respiratory complications were similar in both groups; conversely, there was a higher prevalence of cardiovascular complications in group A (13% vs 3%, P <0.01). Five-year survival was about 35% in both groups. In conclusion, advanced age should no longer be considered an absolute contraindication to esophagectomy for carcinoma in-selected patients. In fact, the postoperative mortality and long-term survival rates of elderly patients undergoing resection are comparable to that of younger individuals.

AB - Advances in perioperative management have allowed more and more elderly patients to undergo major surgery with postoperative morbidity and mortality rates comparable to those of younger individuals. The aim of this study was to evaluate the impact of age on the clinical outcome and long-term survival of patients with esophageal carcinoma undergoing esophagectomy. Nine-hundred patients with esophageal carcinoma were divided into two groups: A (n = 403) with age ≥ 65 years, and B (n = 497) with age <65 years. One-hundred and fifty three (38%) patients of group A underwent surgery compared to 272 (55%) of group B (P <0.01). Postoperative mortality, and the prevalence of anastomotic leak and respiratory complications were similar in both groups; conversely, there was a higher prevalence of cardiovascular complications in group A (13% vs 3%, P <0.01). Five-year survival was about 35% in both groups. In conclusion, advanced age should no longer be considered an absolute contraindication to esophagectomy for carcinoma in-selected patients. In fact, the postoperative mortality and long-term survival rates of elderly patients undergoing resection are comparable to that of younger individuals.

KW - Carcinoma

KW - Elderly age

KW - Esophagus

KW - Postoperative complications

UR - http://www.scopus.com/inward/record.url?scp=0042564779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042564779&partnerID=8YFLogxK

U2 - 10.1046/j.1442-2050.2003.00300.x

DO - 10.1046/j.1442-2050.2003.00300.x

M3 - Article

C2 - 12823204

AN - SCOPUS:0042564779

VL - 16

SP - 90

EP - 93

JO - Diseases of the Esophagus

JF - Diseases of the Esophagus

SN - 1120-8694

IS - 2

ER -