Clinical outcomes and prognostic factors in recurrent and/or metastatic head and neck cancer patients treated with chemotherapy plus cetuximab as first-line therapy in a real-world setting: European Journal of Cancer

R. Depenni, M. Cossu Rocca, D. Ferrari, G. Azzarello, C. Baldessari, M. Alù, F. Nolé, C. Codecà, G. Boscolo, M. Piccininni, S. Cavalieri, P. Bossi

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: The aims of the study are to evaluate the clinical outcomes of first-line treatment with platinum-based chemotherapy and cetuximab in patients with relapsing/metastatic head and neck cancer (RM HNC) and to identify predictors of treatment response. Methods: This is a retrospective, observational, longitudinal, real-world study involving 6 oncology centres in Italy. All consecutive patients with RM HNC treated between January 2007 and December 2016 with a first-line therapy consisting of a platinum-based chemotherapy regimen plus cetuximab were included. The primary objective of the study was to assess overall survival (OS) and progression-free survival (PFS). Secondary objectives included the identification of predictors of treatment response. Results: Overall, 297 patients were identified. Median OS was 10.8 months (95% confidence interval [CI] 9.3–12.2), whereas median PFS was 4.8 months (95% CI 4.3–5.5). On multivariable analysis, independent unfavourable prognostic factors for OS were performance status (PS) Eastern Cooperative Oncology Group (ECOG) >0, presence of residual tumour at primary site, platinum resistance and lack of objective response. Unfavourable predictors for PFS included cancer primary site (paranasal sinuses, hypopharynx), PS ECOG >0, presence of residual tumour at primary site, platinum resistance and lack of objective response. Independent unfavourable predictors of objective response were tumour site (oral cavity, larynx-hypopharynx), residual tumour at primary site and prior chemotherapy. Conclusions: The availability of new treatment modalities and epidemiological changes make the periodic reassessment of prognostic factors of great relevance to guide clinical practice and the design of future randomised clinical trials. © 2019 Elsevier Ltd
Original languageEnglish
Pages (from-to)4-12
Number of pages9
JournalEur. J. Cancer
Volume115
DOIs
Publication statusPublished - 2019

Keywords

  • Cetuximab
  • Head and neck cancer
  • Platinum-based chemotherapy
  • Prognostic factors
  • Relapsing/metastatic disease
  • carboplatin
  • cetuximab
  • cisplatin
  • fluorouracil
  • paclitaxel
  • adult
  • aged
  • Article
  • cancer chemotherapy
  • cancer growth
  • cancer immunotherapy
  • cancer prognosis
  • cancer recurrence
  • cancer resistance
  • clinical outcome
  • comorbidity
  • disease free interval
  • female
  • head and neck cancer
  • human
  • hypopharynx cancer
  • Italy
  • larynx cancer
  • longitudinal study
  • major clinical study
  • male
  • metastasis
  • middle aged
  • mouth cancer
  • observational study
  • oropharynx cancer
  • overall survival
  • paranasal sinus cancer
  • patient history of chemotherapy
  • priority journal
  • progression free survival
  • retrospective study
  • skin cancer
  • treatment response
  • very elderly

Fingerprint Dive into the research topics of 'Clinical outcomes and prognostic factors in recurrent and/or metastatic head and neck cancer patients treated with chemotherapy plus cetuximab as first-line therapy in a real-world setting: European Journal of Cancer'. Together they form a unique fingerprint.

Cite this