TY - JOUR
T1 - Clinical outcomes and safety of patients treated with nab-paclitaxel plus gemcitabine in metastatic pancreatic cancer
T2 - The napa study
AU - Catalano, Martina
AU - Roviello, Giandomenico
AU - Conca, Raffaele
AU - D’angelo, Alberto
AU - Palmieri, Valeria Emma
AU - Panella, Benedetta
AU - Petrioli, Roberto
AU - Ianza, Anna
AU - Nobili, Stefania
AU - Mini, Enrico
AU - Ramello, Monica
N1 - Publisher Copyright:
© 2020 Bentham Science Publishers.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Background: The phase III MPACT trial demonstrated the superiority of gemcitabine (Gem) combined with Nab-paclitaxel (Nab-P) versus gemcitabine alone in previously untreated patients with metastatic pancreatic ductal adenocarcinoma (PDAC). The purpose of this study was to evaluate the effect of Gem/Nab-P in routine clinical practice. Methods: From January 2015 to December 2018, patients with metastatic PDAC receiving first-line treatment with a combination of gemcitabine and Nab-paclitaxel were included in a multicen-tre retrospective observational study. Exploratory analyses of efficacy, and prognostic and predictive markers, were performed. Results: The cohort comprised 115 patients (median age 65 [range 50-84] years) with good perfor-mance status (ECOG PS 0-1). The median overall survival (OS) was 11 months (95% CI; 9-13) and the median progression-free survival (PFS) was 6 months (95% CI 5-7). Partial response and stable disease were achieved in 44 and 30 patients, respectively, yielding an overall disease control rate (DCR) of 64.3%. Grade 3-4 hematological toxicity frequency was 22.61% for neutropenia, 5.22% for anemia, and 3.48% for thrombocytopenia. Grade 3 asthenia was recorded in 2.61% of pa-tients. No grade 4 non-hematological events were reported. Dose reduction was necessary in 51.3% of the patients. Conclusion: Our results confirm the efficacy and safety of a first-line regimen comprising gemc-itabine and Nab-paclitaxel in metastatic PDAC in a real-life population.
AB - Background: The phase III MPACT trial demonstrated the superiority of gemcitabine (Gem) combined with Nab-paclitaxel (Nab-P) versus gemcitabine alone in previously untreated patients with metastatic pancreatic ductal adenocarcinoma (PDAC). The purpose of this study was to evaluate the effect of Gem/Nab-P in routine clinical practice. Methods: From January 2015 to December 2018, patients with metastatic PDAC receiving first-line treatment with a combination of gemcitabine and Nab-paclitaxel were included in a multicen-tre retrospective observational study. Exploratory analyses of efficacy, and prognostic and predictive markers, were performed. Results: The cohort comprised 115 patients (median age 65 [range 50-84] years) with good perfor-mance status (ECOG PS 0-1). The median overall survival (OS) was 11 months (95% CI; 9-13) and the median progression-free survival (PFS) was 6 months (95% CI 5-7). Partial response and stable disease were achieved in 44 and 30 patients, respectively, yielding an overall disease control rate (DCR) of 64.3%. Grade 3-4 hematological toxicity frequency was 22.61% for neutropenia, 5.22% for anemia, and 3.48% for thrombocytopenia. Grade 3 asthenia was recorded in 2.61% of pa-tients. No grade 4 non-hematological events were reported. Dose reduction was necessary in 51.3% of the patients. Conclusion: Our results confirm the efficacy and safety of a first-line regimen comprising gemc-itabine and Nab-paclitaxel in metastatic PDAC in a real-life population.
KW - Cancer
KW - Combined chemotherapy
KW - Gemcitabine
KW - Metastatic pancreatic adenocarcinoma
KW - Nab-paclitaxel
KW - Prognostic factor
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U2 - 10.2174/1568009620999200918122426
DO - 10.2174/1568009620999200918122426
M3 - Article
C2 - 32957885
AN - SCOPUS:85095410791
VL - 20
SP - 887
EP - 895
JO - Current Cancer Drug Targets
JF - Current Cancer Drug Targets
SN - 1568-0096
IS - 11
ER -