Clinical outcomes of calcified nodules detected by optical coherence tomography: a sub-analysis of the CLIMA study

Francesco Prati, Laura Gatto, Franco Fabbiocchi, Rocco Vergallo, Giulia Paoletti, Giovanni Ruscica, Valeria Marco, Enrico Romagnoli, Alberto Boi, Massimo Fineschi, Giuseppe Calligaris, Corrado Tamburino, Filippo Crea, Yukio Ozaki, Fernando Alfonso, Eloisa Arbustini

Research output: Contribution to journalArticlepeer-review

Abstract

AIMS: The goal of the present post hoc analysis of the CLIMA registry was to establish the relationship between calcified nodules (CNs) with (CND) or without (CNWD) disruption of the superficial intimal fibrous layer and one-year occurrence of target lesion myocardial infarction (MI) and/or cardiac death.

METHODS AND RESULTS: CND and CNWD were identified based on the presence or absence of superficial irregularities indicative of disruption of the intimal fibrous layer, with possible overlying local thrombus. In total, 222 CNs were found in the 1,776 non-culprit LAD plaques. CND had larger maximum calcific arc and smaller lumen area. Cardiac death and MI occurred in 20% of patients in the CND group versus 2.7% in the CNWD group and 3.3% in the group without CN (p<0.001). This figure was mainly due to the 13.3% incidence of cardiac death in the CND group versus 2.0% in the CNWD group and versus 2.2% in the group without CN (p<0.001). The presence of CND was confirmed as an independent predictor of events (HR 6.58, 95% CI: 2.7-15.8, p<0.001).

CONCLUSIONS: The presence of CND was associated with a high one-year incidence of cardiac death and/or target lesion MI.

Original languageEnglish
Pages (from-to)380-386
Number of pages7
JournalEuroIntervention
Volume16
Issue number5
DOIs
Publication statusPublished - Aug 28 2020

Keywords

  • Coronary Angiography
  • Humans
  • Incidence
  • Myocardial Infarction/epidemiology
  • Plaque, Atherosclerotic/diagnostic imaging
  • Tomography, Optical Coherence

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