Clinical outcomes of Clostridium difficile infection according to strain type. A prospective study in medical wards

S. Serafino, D. Consonni, M. Migone De Amicis, F. Sisto, G. Domeniconi, S. Formica, M. Zarantonello, A. Maraschini, M. D. Cappellini, P. Spigaglia, F. Barbanti, S. Castaldi, G. Fabio

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: To describe clinical characteristics and outcome of Clostridium difficile infection (CDI) patients in Internal Medicine, to identify ribotypes (RTs); to evaluate the association between RT and patient clinical characteristics and report outcome. Methods: One year prospective cohort study. Clinical data, Barthel Index (BI) and outcomes were collected for all inpatients suffering from CDI (n = 148) in hospital wards in Northern Italy. 84 fecal samples were analysed for molecular typing. Results: 12 RTs were identified, predominantly RT018 (42.9%, n = 36/84) and RT356/607 (40.5%, n = 34/84). Patients with dementia were more frequent among those infected by RT018 [55.6% (n = 20/36) vs. 32.4% (n = 11/34), p = 0.05]. The median BI score of patients with RT018 was lower than BI score of patients with RT356/607 [10 (IQR 0–32) vs. 15 (IQR 5–50), p = 0.06]. RT018 infection was associated to higher levels of C-reactive protein [7.2 mg/dl (IQR 4.1–14.7) vs. 4.0 mg/dl (IQR 2.2–6.8), p = 0.01] and white blood cells ≥15,000/dl [33.3% (n = 12/36) vs. 14.7% (n = 5/34) of patients, p = 0.07]. Higher mortality was noted among RT018 infected patients. We found a continuous mortality increase according to the ATLAS score. Conclusions: Our results confirm that RT018 and RT356/607 are the two major RTs causing CDI in older patients with a high degree of disability in Northern Italy and RT018 is associated with more serious outcomes.

Original languageEnglish
Pages (from-to)21-26
JournalEuropean Journal of Internal Medicine
Volume54
DOIs
Publication statusPublished - 2018

Fingerprint

Clostridium Infections
Clostridium difficile
Prospective Studies
Ribotyping
Italy
Molecular Typing
Mortality
Internal Medicine
C-Reactive Protein
Dementia
Inpatients
Leukocytes
Cohort Studies

Keywords

  • ATLAS score
  • Barthel index
  • Clinical outcomes
  • Clostridium difficile infection
  • PCR-ribotype 018
  • PCR-ribotype 356/607

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Clinical outcomes of Clostridium difficile infection according to strain type. A prospective study in medical wards. / Serafino, S.; Consonni, D.; Migone De Amicis, M.; Sisto, F.; Domeniconi, G.; Formica, S.; Zarantonello, M.; Maraschini, A.; Cappellini, M. D.; Spigaglia, P.; Barbanti, F.; Castaldi, S.; Fabio, G.

In: European Journal of Internal Medicine, Vol. 54, 2018, p. 21-26.

Research output: Contribution to journalArticle

Serafino, S. ; Consonni, D. ; Migone De Amicis, M. ; Sisto, F. ; Domeniconi, G. ; Formica, S. ; Zarantonello, M. ; Maraschini, A. ; Cappellini, M. D. ; Spigaglia, P. ; Barbanti, F. ; Castaldi, S. ; Fabio, G. / Clinical outcomes of Clostridium difficile infection according to strain type. A prospective study in medical wards. In: European Journal of Internal Medicine. 2018 ; Vol. 54. pp. 21-26.
@article{7608645f2d0d473486b42d32eb3ef268,
title = "Clinical outcomes of Clostridium difficile infection according to strain type. A prospective study in medical wards",
abstract = "Objectives: To describe clinical characteristics and outcome of Clostridium difficile infection (CDI) patients in Internal Medicine, to identify ribotypes (RTs); to evaluate the association between RT and patient clinical characteristics and report outcome. Methods: One year prospective cohort study. Clinical data, Barthel Index (BI) and outcomes were collected for all inpatients suffering from CDI (n = 148) in hospital wards in Northern Italy. 84 fecal samples were analysed for molecular typing. Results: 12 RTs were identified, predominantly RT018 (42.9{\%}, n = 36/84) and RT356/607 (40.5{\%}, n = 34/84). Patients with dementia were more frequent among those infected by RT018 [55.6{\%} (n = 20/36) vs. 32.4{\%} (n = 11/34), p = 0.05]. The median BI score of patients with RT018 was lower than BI score of patients with RT356/607 [10 (IQR 0–32) vs. 15 (IQR 5–50), p = 0.06]. RT018 infection was associated to higher levels of C-reactive protein [7.2 mg/dl (IQR 4.1–14.7) vs. 4.0 mg/dl (IQR 2.2–6.8), p = 0.01] and white blood cells ≥15,000/dl [33.3{\%} (n = 12/36) vs. 14.7{\%} (n = 5/34) of patients, p = 0.07]. Higher mortality was noted among RT018 infected patients. We found a continuous mortality increase according to the ATLAS score. Conclusions: Our results confirm that RT018 and RT356/607 are the two major RTs causing CDI in older patients with a high degree of disability in Northern Italy and RT018 is associated with more serious outcomes.",
keywords = "ATLAS score, Barthel index, Clinical outcomes, Clostridium difficile infection, PCR-ribotype 018, PCR-ribotype 356/607",
author = "S. Serafino and D. Consonni and {Migone De Amicis}, M. and F. Sisto and G. Domeniconi and S. Formica and M. Zarantonello and A. Maraschini and Cappellini, {M. D.} and P. Spigaglia and F. Barbanti and S. Castaldi and G. Fabio",
year = "2018",
doi = "10.1016/j.ejim.2018.03.015",
language = "English",
volume = "54",
pages = "21--26",
journal = "European Journal of Internal Medicine",
issn = "0953-6205",
publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Clinical outcomes of Clostridium difficile infection according to strain type. A prospective study in medical wards

AU - Serafino, S.

AU - Consonni, D.

AU - Migone De Amicis, M.

AU - Sisto, F.

AU - Domeniconi, G.

AU - Formica, S.

AU - Zarantonello, M.

AU - Maraschini, A.

AU - Cappellini, M. D.

AU - Spigaglia, P.

AU - Barbanti, F.

AU - Castaldi, S.

AU - Fabio, G.

PY - 2018

Y1 - 2018

N2 - Objectives: To describe clinical characteristics and outcome of Clostridium difficile infection (CDI) patients in Internal Medicine, to identify ribotypes (RTs); to evaluate the association between RT and patient clinical characteristics and report outcome. Methods: One year prospective cohort study. Clinical data, Barthel Index (BI) and outcomes were collected for all inpatients suffering from CDI (n = 148) in hospital wards in Northern Italy. 84 fecal samples were analysed for molecular typing. Results: 12 RTs were identified, predominantly RT018 (42.9%, n = 36/84) and RT356/607 (40.5%, n = 34/84). Patients with dementia were more frequent among those infected by RT018 [55.6% (n = 20/36) vs. 32.4% (n = 11/34), p = 0.05]. The median BI score of patients with RT018 was lower than BI score of patients with RT356/607 [10 (IQR 0–32) vs. 15 (IQR 5–50), p = 0.06]. RT018 infection was associated to higher levels of C-reactive protein [7.2 mg/dl (IQR 4.1–14.7) vs. 4.0 mg/dl (IQR 2.2–6.8), p = 0.01] and white blood cells ≥15,000/dl [33.3% (n = 12/36) vs. 14.7% (n = 5/34) of patients, p = 0.07]. Higher mortality was noted among RT018 infected patients. We found a continuous mortality increase according to the ATLAS score. Conclusions: Our results confirm that RT018 and RT356/607 are the two major RTs causing CDI in older patients with a high degree of disability in Northern Italy and RT018 is associated with more serious outcomes.

AB - Objectives: To describe clinical characteristics and outcome of Clostridium difficile infection (CDI) patients in Internal Medicine, to identify ribotypes (RTs); to evaluate the association between RT and patient clinical characteristics and report outcome. Methods: One year prospective cohort study. Clinical data, Barthel Index (BI) and outcomes were collected for all inpatients suffering from CDI (n = 148) in hospital wards in Northern Italy. 84 fecal samples were analysed for molecular typing. Results: 12 RTs were identified, predominantly RT018 (42.9%, n = 36/84) and RT356/607 (40.5%, n = 34/84). Patients with dementia were more frequent among those infected by RT018 [55.6% (n = 20/36) vs. 32.4% (n = 11/34), p = 0.05]. The median BI score of patients with RT018 was lower than BI score of patients with RT356/607 [10 (IQR 0–32) vs. 15 (IQR 5–50), p = 0.06]. RT018 infection was associated to higher levels of C-reactive protein [7.2 mg/dl (IQR 4.1–14.7) vs. 4.0 mg/dl (IQR 2.2–6.8), p = 0.01] and white blood cells ≥15,000/dl [33.3% (n = 12/36) vs. 14.7% (n = 5/34) of patients, p = 0.07]. Higher mortality was noted among RT018 infected patients. We found a continuous mortality increase according to the ATLAS score. Conclusions: Our results confirm that RT018 and RT356/607 are the two major RTs causing CDI in older patients with a high degree of disability in Northern Italy and RT018 is associated with more serious outcomes.

KW - ATLAS score

KW - Barthel index

KW - Clinical outcomes

KW - Clostridium difficile infection

KW - PCR-ribotype 018

KW - PCR-ribotype 356/607

UR - http://www.scopus.com/inward/record.url?scp=85045050629&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045050629&partnerID=8YFLogxK

U2 - 10.1016/j.ejim.2018.03.015

DO - 10.1016/j.ejim.2018.03.015

M3 - Article

AN - SCOPUS:85045050629

VL - 54

SP - 21

EP - 26

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

SN - 0953-6205

ER -