Clinical outcomes of elderly patients with bloodstream infections due to extended-spectrum β-lactamase-producing Enterobacteriaceae in an Italian Internal Medicine ward

Simone Meini, Raffaele Laureano, Carlo Tascini, Fabio Arena, Lucia Fani, Anna Frullini, Maria Teresa Passaleva, Anna Teresa Roberts, Dario Mannini, Francesco Sbrana, Andrea Ripoli, Gian Maria Rossolini

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Infections caused by ESBL-producing Enterobacteriaceae (ESBL-EB) are a major health problem, but data regarding elderly patients is lacking. Methods: We performed a retrospective observational study quantifying the effects of antimicrobial treatment and primary infection site on clinical outcomes in an historical case series of 42 patients aged 80.7. ±. 10. years admitted to an Internal Medicine ward in Italy for ESBL-EB bloodstream infections (BSI). Results: At multivariate risk analysis, we found that urinary tract as primary infection site (RR = 0.181 [0.037-0.886], p = 0.035) and definitive antibiotic therapy (RR = 0.517 [0.147-0.799], p = 0.038) decreased the relative risk of a negative clinical response, while the respiratory tract origin increased the relative risk (RR = 2.788 [1.407-9.228], p = 0.025).Also regarding 30. days mortality, multivariate risk analysis identified that urinary tract as primary infection site (RR = 0.098 [0.011-0.743], p = 0.025) and definitive antibiotic therapy (RR = 0.236 [0.058-0.961], p = 0.044) decreased the relative risk, while the respiratory origin increased the relative risk (RR = 4.241 [1.040-17.295], p = 0.014).We observed similar outcomes in patients definitively treated with carbapenems or with carbapenem-free treatments. Additionally, an initially inappropriate therapy did not correlate with worse outcomes if a switch to an effective definitive treatment was performed promptly. Conclusions: Carbapenem-sparing regimens (e.g. piperacillin-tazobactam alone or with an aminoglycoside) could be empirically safely used in elderly patients at high risk of ESBL-EB BSI and for definitive treatment of ascertained cases if the primary site is the urinary tract, leaving early carbapenem use for cases at higher risk of death, such as those with pneumonia.

Original languageEnglish
JournalEuropean Journal of Internal Medicine
DOIs
Publication statusE-pub ahead of print - Oct 2017

Keywords

  • Carbapenem
  • Elderly
  • Enterobacteriaceae
  • ESBL
  • Internal medicine
  • Outcome

ASJC Scopus subject areas

  • Internal Medicine

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