Clinical performance of contrast-enhanced spectral mammography in pre-surgical evaluation of breast malignant lesions in dense breasts: a single center study.

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Abstract

PURPOSE: To compare the efficacy of contrast-enhanced spectral mammography, with ultrasound, full field digital mammography and magnetic resonance imaging in detection and size estimation of histologically proven breast tumors. METHODS: This open-label, single center, prospective study, included 160 dense breast women with at least one suspicious mammary lesion evaluated by ultrasound, full field digital mammography and magnetic resonance imaging in whom a mammary tumor was histologically proven after surgery performed at the European Institute of Oncology between January 2013 and December 2015. Following the complete diagnostic procedure, the patients were further investigated by contrast-enhanced spectral mammography prior to surgery. RESULTS: Overall, the detection rate of malignant breast lesions (in situ and invasive) was 93.8165/176) for contrast-enhanced spectral mammography, 94.4168/178) for ultrasound, 85.5 (147/172) for full field digital mammography and 97.7173/177) for magnetic resonance imaging. Radiological measurements were concordant with the post-surgical pathological measurements of the invasive tumor (i.e., within 5 mm) in: 64.6enhanced spectral mammography, 62.0 45.2p textless 0.0001) and 69.9p = 0.28); underestimated in: 17.4enhanced spectral mammography, 19.6 24.2p = 0.03) and 6.7p = 0.0005); and overestimated in: 16.2enhanced spectral mammography, 16.6 16.62.7p = 0.02). CONCLUSIONS: Our data suggest that contrast-enhanced spectral mammography improves on full field digital mammography and is comparable to ultrasound and magnetic resonance imaging in terms of detection sensitivity and size estimation of malignant lesions in dense breasts.
Original languageEnglish
JournalBreast Cancer Research and Treatment
Issue number3
Publication statusPublished - Dec 1 2020

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