Clinical pharmacology of intraperitoneal cisplatin-based chemotherapy

Matteo Conti, U. De Giorgi, V. Tazzari, F. Bezzi, C. Baccini

Research output: Contribution to journalArticle

Abstract

The management of intraperitoneal tumors, especially when confined to the peritoneal cavity and/or associated with malignant ascites, requires the use of intraperitoneal (i.p.) cisplatin-based chemotherapy. This therapeutic approach, enabling high concentrations of drug and long duration of tumor tissue exposure, while generating a systemic exposure similar to that obtained with intravenous (i.v.) infusion, significantly improves therapeutic ratio. Nowadays, as feasibility issues are easy to overcome, intraperitoneal chemotherapy provides a safe, effective treatment for the management of peritoneal disease, particularly ovarian carcinoma. In this paper we review pharmacological issues of intraperitoneal cispiatin-based chemotherapy in order to provide a ready to use information collection for clinical practice and ongoing research.

Original languageEnglish
Pages (from-to)23-25
Number of pages3
JournalJournal of Chemotherapy
Volume16
Issue numberSUPPL. 5
Publication statusPublished - Nov 2004

Fingerprint

Clinical Pharmacology
Cisplatin
Drug Therapy
Peritoneal Diseases
Peritoneal Cavity
Ascites
Intravenous Infusions
Neoplasms
Therapeutics
Pharmacology
Carcinoma
Research
Pharmaceutical Preparations

Keywords

  • Cisplatin
  • Clinical pharmacology
  • Intraperitoneal chemotherapy

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)

Cite this

Conti, M., De Giorgi, U., Tazzari, V., Bezzi, F., & Baccini, C. (2004). Clinical pharmacology of intraperitoneal cisplatin-based chemotherapy. Journal of Chemotherapy, 16(SUPPL. 5), 23-25.

Clinical pharmacology of intraperitoneal cisplatin-based chemotherapy. / Conti, Matteo; De Giorgi, U.; Tazzari, V.; Bezzi, F.; Baccini, C.

In: Journal of Chemotherapy, Vol. 16, No. SUPPL. 5, 11.2004, p. 23-25.

Research output: Contribution to journalArticle

Conti, M, De Giorgi, U, Tazzari, V, Bezzi, F & Baccini, C 2004, 'Clinical pharmacology of intraperitoneal cisplatin-based chemotherapy', Journal of Chemotherapy, vol. 16, no. SUPPL. 5, pp. 23-25.
Conti M, De Giorgi U, Tazzari V, Bezzi F, Baccini C. Clinical pharmacology of intraperitoneal cisplatin-based chemotherapy. Journal of Chemotherapy. 2004 Nov;16(SUPPL. 5):23-25.
Conti, Matteo ; De Giorgi, U. ; Tazzari, V. ; Bezzi, F. ; Baccini, C. / Clinical pharmacology of intraperitoneal cisplatin-based chemotherapy. In: Journal of Chemotherapy. 2004 ; Vol. 16, No. SUPPL. 5. pp. 23-25.
@article{2c3779ab5c6242b9adde00ef6b741081,
title = "Clinical pharmacology of intraperitoneal cisplatin-based chemotherapy",
abstract = "The management of intraperitoneal tumors, especially when confined to the peritoneal cavity and/or associated with malignant ascites, requires the use of intraperitoneal (i.p.) cisplatin-based chemotherapy. This therapeutic approach, enabling high concentrations of drug and long duration of tumor tissue exposure, while generating a systemic exposure similar to that obtained with intravenous (i.v.) infusion, significantly improves therapeutic ratio. Nowadays, as feasibility issues are easy to overcome, intraperitoneal chemotherapy provides a safe, effective treatment for the management of peritoneal disease, particularly ovarian carcinoma. In this paper we review pharmacological issues of intraperitoneal cispiatin-based chemotherapy in order to provide a ready to use information collection for clinical practice and ongoing research.",
keywords = "Cisplatin, Clinical pharmacology, Intraperitoneal chemotherapy",
author = "Matteo Conti and {De Giorgi}, U. and V. Tazzari and F. Bezzi and C. Baccini",
year = "2004",
month = "11",
language = "English",
volume = "16",
pages = "23--25",
journal = "Journal of Chemotherapy",
issn = "1120-009X",
publisher = "Maney Publishing",
number = "SUPPL. 5",

}

TY - JOUR

T1 - Clinical pharmacology of intraperitoneal cisplatin-based chemotherapy

AU - Conti, Matteo

AU - De Giorgi, U.

AU - Tazzari, V.

AU - Bezzi, F.

AU - Baccini, C.

PY - 2004/11

Y1 - 2004/11

N2 - The management of intraperitoneal tumors, especially when confined to the peritoneal cavity and/or associated with malignant ascites, requires the use of intraperitoneal (i.p.) cisplatin-based chemotherapy. This therapeutic approach, enabling high concentrations of drug and long duration of tumor tissue exposure, while generating a systemic exposure similar to that obtained with intravenous (i.v.) infusion, significantly improves therapeutic ratio. Nowadays, as feasibility issues are easy to overcome, intraperitoneal chemotherapy provides a safe, effective treatment for the management of peritoneal disease, particularly ovarian carcinoma. In this paper we review pharmacological issues of intraperitoneal cispiatin-based chemotherapy in order to provide a ready to use information collection for clinical practice and ongoing research.

AB - The management of intraperitoneal tumors, especially when confined to the peritoneal cavity and/or associated with malignant ascites, requires the use of intraperitoneal (i.p.) cisplatin-based chemotherapy. This therapeutic approach, enabling high concentrations of drug and long duration of tumor tissue exposure, while generating a systemic exposure similar to that obtained with intravenous (i.v.) infusion, significantly improves therapeutic ratio. Nowadays, as feasibility issues are easy to overcome, intraperitoneal chemotherapy provides a safe, effective treatment for the management of peritoneal disease, particularly ovarian carcinoma. In this paper we review pharmacological issues of intraperitoneal cispiatin-based chemotherapy in order to provide a ready to use information collection for clinical practice and ongoing research.

KW - Cisplatin

KW - Clinical pharmacology

KW - Intraperitoneal chemotherapy

UR - http://www.scopus.com/inward/record.url?scp=11144239617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11144239617&partnerID=8YFLogxK

M3 - Article

C2 - 15675471

AN - SCOPUS:11144239617

VL - 16

SP - 23

EP - 25

JO - Journal of Chemotherapy

JF - Journal of Chemotherapy

SN - 1120-009X

IS - SUPPL. 5

ER -