Clinical pig liver xenotransplantation: How far do we have to go?

Burcin Ekser, Bruno Gridelli, Massimiliano Veroux, David K C Cooper

Research output: Contribution to journalArticle

Abstract

As pigs are currently the preferred species for organ xenotransplantation, initial experience in liver xenotransplantation with wild-type (WT) pigs, advances in the development of genetically modified pigs, and recent studies using livers from them are reviewed. The xenotransplantation of livers from pigs transgenic for the human complement regulatory protein (CRP) CD55 or from α1,3-galactosyltransferase gene-knockout pigs+/- additionally transgenic for the CRP CD46 (GTKO/CD46 pigs) is associated with the survival of approximately 1 week. Satisfactory hepatic function has been documented, lending support to the concept that the pig liver might provide a bridge to allotransplantation. However, although significant features of rejection have not been documented, the development of an immediate thrombocytopenia after graft reperfusion is problematic and leads to spontaneous hemorrhage within the body cavities, native organs, and graft. Current studies are being directed to understand the factors causing the activation, aggregation, or phagocytosis of platelets, in particular the interaction between platelets and liver sinusoidal endothelial cells, hepatocytes, and Kupffer cells. If this problem can be resolved, a clinical trial of pig liver xenotransplantation as a bridge to allotransplantation may be both feasible and justified.

Original languageEnglish
Pages (from-to)158-167
Number of pages10
JournalXenotransplantation
Volume18
Issue number3
DOIs
Publication statusPublished - May 2011

Keywords

  • α1,3-galactosyltransferase gene knockout
  • hCD46
  • liver
  • liver failure, acute
  • non-human primate
  • pig
  • xenotransplantation

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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