Abstract
Preoperative chemoradiotherapy is worldwide accepted as a standard treatment for locally advanced rectal cancer. Current standard of treatment includes administration of ionizing radiation for 45-50.4Gy in 25-28 fractions associated with 5-fluorouracil administration during radiation therapy. Unfortunately, 40% of patients have a poor or absent response and novel predictive biomarkers are demanding. For the first time, we apply a novel peptidomic methodology and analysis in rectal cancer patients treated with preoperative chemoradiotherapy. Circulating peptides (Molecular Weight
| Original language | English |
|---|---|
| Pages (from-to) | 1822-1828 |
| Number of pages | 7 |
| Journal | Journal of Cellular Physiology |
| Volume | 230 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 1 2015 |
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ASJC Scopus subject areas
- Clinical Biochemistry
- Cell Biology
- Physiology
- Medicine(all)
Cite this
Clinical Predictive Circulating Peptides in Rectal Cancer Patients Treated with Neoadjuvant Chemoradiotherapy. / Crotti, Sara; Enzo, Maria Vittoria; Bedin, Chiara; Pucciarelli, Salvatore; Maretto, Isacco; Del Bianco, Paola; Traldi, Pietro; Tasciotti, Ennio; Ferrari, Mauro; Rizzolio, Flavio; Toffoli, Giuseppe; Giordano, Antonio; Nitti, Donato; Agostini, Marco.
In: Journal of Cellular Physiology, Vol. 230, No. 8, 01.08.2015, p. 1822-1828.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical Predictive Circulating Peptides in Rectal Cancer Patients Treated with Neoadjuvant Chemoradiotherapy
AU - Crotti, Sara
AU - Enzo, Maria Vittoria
AU - Bedin, Chiara
AU - Pucciarelli, Salvatore
AU - Maretto, Isacco
AU - Del Bianco, Paola
AU - Traldi, Pietro
AU - Tasciotti, Ennio
AU - Ferrari, Mauro
AU - Rizzolio, Flavio
AU - Toffoli, Giuseppe
AU - Giordano, Antonio
AU - Nitti, Donato
AU - Agostini, Marco
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Preoperative chemoradiotherapy is worldwide accepted as a standard treatment for locally advanced rectal cancer. Current standard of treatment includes administration of ionizing radiation for 45-50.4Gy in 25-28 fractions associated with 5-fluorouracil administration during radiation therapy. Unfortunately, 40% of patients have a poor or absent response and novel predictive biomarkers are demanding. For the first time, we apply a novel peptidomic methodology and analysis in rectal cancer patients treated with preoperative chemoradiotherapy. Circulating peptides (Molecular Weight
AB - Preoperative chemoradiotherapy is worldwide accepted as a standard treatment for locally advanced rectal cancer. Current standard of treatment includes administration of ionizing radiation for 45-50.4Gy in 25-28 fractions associated with 5-fluorouracil administration during radiation therapy. Unfortunately, 40% of patients have a poor or absent response and novel predictive biomarkers are demanding. For the first time, we apply a novel peptidomic methodology and analysis in rectal cancer patients treated with preoperative chemoradiotherapy. Circulating peptides (Molecular Weight
UR - http://www.scopus.com/inward/record.url?scp=84928394287&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928394287&partnerID=8YFLogxK
U2 - 10.1002/jcp.24894
DO - 10.1002/jcp.24894
M3 - Article
VL - 230
SP - 1822
EP - 1828
JO - Journal of cellular and comparative physiology
JF - Journal of cellular and comparative physiology
SN - 0021-9541
IS - 8
ER -