Clinical predictors for germline mutations in Head and neck paraganglioma patients: cost reduction strategy in Genetic diagnostic process as fail-out

Hartmut P H Neumann, Zoran Erlic, Carsten C. Boedeker, Lisa A. Rybicki, Mercedes Robledo, Mario Hermsen, Francesca Schiavi, Maurizio Falcioni, Pingling Kwok, Catherine Bauters, Karen Lampe, Markus Fischer, Emily Edelman, Diana E. Benn, Bruce G. Robinson, Stefanie Wiegand, Gerd Rasp, Boris A. Stuck, Michael M. Hoffmann, Maren SullivanMaria A. Sevilla, Marjan M. Weiss, Mariola Peczkowska, Agata Kubaszek, Pascal Pigny, Robyn L. Ward, Diana Learoyd, Michael Croxson, Dmitry Zabolotny, Svetlana Yaremchuk, Wolfgang Dra, Mihaela Muresan, Robert R. Lorenz, Stephan Knipping, Michael Strohm, Gerhard Dyckhoff, Christoph Matthias, Nicole Reisch, Simon F. Preuss, Dirk Eßer, Martin A. Walter, Holger Kaftan, Timo Stöver, Christian Fottner, Harald Gorgulla, Mahdi Malekpour, Masoud Motasaddi Zarandy, Jorg Schipper, Christoph Brase, Alexander Glien, Matthias Kühnemund, Sven Koseielny, Peter Schwerdtfeger, Matti Välimäki, Witold Szyfter, Ulrich Finckh, Klaus Zerres, Alberto Cascon, Giuseppe Opocher, Gerd J. Ridder, Andrzej Januszewicz, Carlos Suarez, Charis Eng

Research output: Contribution to journalArticle

Abstract

Multiple genes and their variants that lend susceptibility to many diseases will play a major role in clinical routine. Genetics-based cost reduction strategies in diagnostic processes are important in the setting of multiple susceptibility genes for a single disease. Head and neck paraganglioma (HNP) is caused by germline mutations of at least three succinate dehydrogenase subunit genes (SDHx). Mutation analysis for all 3 costs ~ US$2,700 per patient. Genetic classification is essential for downstream management of the patient and preemptive management of family members. Utilizing HNP as a model, we wanted to determine predictors to prioritize the most heritable clinical presentations and which gene to begin testing in HNP presentations, to reduce costs of genetic screening. Patients were tested for SDHB, SDHC, and SDHD intragenic mutations and large deletions. Clinical parameters were analyzed as potential predictors for finding germline mutations. Cost reduction was calculated between prioritized gene testing compared with that for all genes. Of 598 patients, 30.6% had SDHx germline mutations: 34.4% in SDHB, 14.2% SDHC, and 51.4% SDHD. Predictors for an SDHx mutation are family history [odds ratio (OR), 37.9], previous pheochromocytoma (OR, 10.9), multiple HNP (OR, 10.6), age ≤40 years (OR, 4.0), and male gender (OR, 3.5). By screening only preselected cases and a stepwise approach, 60% cost reduction can be achieved, with 91.8% sensitivity and 94.5% negative predictive value. Our data give evidence that clinical parameters can predict for mutation and help prioritize gene testing to reduce costs in HNP. Such strategy is cost-saving in the practice of genetics-based personalized health care.

Original languageEnglish
Pages (from-to)3650-3656
Number of pages7
JournalCancer Research
Volume69
Issue number8
DOIs
Publication statusPublished - Apr 15 2009

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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