Clinical predictors of marked improvement in left ventricular performance after cardiac resynchronization therapy in patients with chronic heart failure

Maurizio Mangiavacchi, Maurizio Gasparini, Francesco Faletra, Catherine Klersy, Emanuela Morenghi, Paola Galimberti, Luca Genovese, François Regoli, Francesca De Chiara, Renato Bragato, Bruno Andreuzzi, Daniela Pini, Edoardo Gronda

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Abstract

Background: Previous studies have shown that cardiac resynchronization therapy (CRT) improves cardiac performance and decreases mortality and hospital admission rates. However, it is not yet clear which patients will benefit from the procedure the most. The purpose of the study was to identify the pre-implant characteristics that better predict which patients will have the best outcome after CRT. Methods: In this observational study, 156 patients were studied with echocardiography and a 6-minute walking test at baseline and 12 months after CRT. Results: After CRT, we observed an increase in left ventricular ejection fraction (+29.6%, P <.0001), a decrease in left ventricular end systolic volume (-26.4%, P <.0001), in the proportion of patients with grade 2-4 mitral regurgitation (from 47.1% to 34.0%, P = .002), and with NYHA functional class III-IV (from 83.2% to 11.6%, P <.0001), an increase in exercise tolerance (+31.1%, P <.0001). Sixty-two patients had a marked increase in left ventricular ejection fraction (>10 units); the only independent predictor of a marked effect of CRT was the nonischemic etiology of heart failure. In patients with ischemic cardiomyopathy, the benefit on ejection fraction correlates inversely with the extension of the ischemic damage. Conclusions: CRT improves left ventricular function and exercise tolerance in the long term. The nonischemic etiology of the cardiomyopathy is the only independent predictor of a marked effect of CRT; this is probably due to the absence of ischemic, nonviable scar tissue in these patients.

Original languageEnglish
JournalAmerican Heart Journal
Volume151
Issue number2
DOIs
Publication statusPublished - Feb 2006

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Cardiac Resynchronization Therapy
Heart Failure
Cardiomyopathies
Exercise Tolerance
Hospital Mortality
Left Ventricular Function
Stroke Volume
Walking
Cicatrix
Observational Studies
Echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Clinical predictors of marked improvement in left ventricular performance after cardiac resynchronization therapy in patients with chronic heart failure. / Mangiavacchi, Maurizio; Gasparini, Maurizio; Faletra, Francesco; Klersy, Catherine; Morenghi, Emanuela; Galimberti, Paola; Genovese, Luca; Regoli, François; De Chiara, Francesca; Bragato, Renato; Andreuzzi, Bruno; Pini, Daniela; Gronda, Edoardo.

In: American Heart Journal, Vol. 151, No. 2, 02.2006.

Research output: Contribution to journalArticle

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AU - Morenghi, Emanuela

AU - Galimberti, Paola

AU - Genovese, Luca

AU - Regoli, François

AU - De Chiara, Francesca

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AU - Gronda, Edoardo

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