Abstract
Introduction The role of thrombophilia screening and antithrombotic therapy in unselected women undergone Assisted Reproductive Technologies (ART) is largely unknown. Nonetheless, in many Countries infertile women undergo thrombophilia screening and/or antithrombotic therapy. Materials and Methods We carried out a follow-up study. The original sample (n = 1107) consisted of infertile women observed in 13 years. A cohort of 157 women with at least 1 cycle before thrombophilia test and 1 after test was investigated. All underwent thrombophilia screening; an antithrombotic treatment was prescribed in 216 out of 801 cycles. Clinical pregnancy and live birth rates were the main clinical objectives. Results Overall, 15 (9.6%) women carried thrombophilia. The Cox regression showed that LMWH alone or combined with ASA was significantly associated with the outcome "live birth" "live births" (p: 0.015, HR: 2.8, 95%CI: 1.2-6.6 for combined therapy), independently of the carriership of thrombophilia. Women with a lower number of attempts had a higher likelihood of delivering a live-born child using the combined therapy (p <0.001, HR: 0.7, 95%CI: 0.7-0.8), independently of the presence of thrombophilia. Conclusions A potential benefit of LMWH in improving number of live births, independently of the presence of thrombophilia, is suggested. Universal thrombophilia screening before ART is not useful to discriminate women with a worse pregnancy prognosis.
| Original language | English |
|---|---|
| Pages (from-to) | 168-172 |
| Number of pages | 5 |
| Journal | Thrombosis Research |
| Volume | 133 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2014 |
Fingerprint
ASJC Scopus subject areas
- Hematology
Cite this
Clinical Pregnancies and Live Births in women approaching ART : A follow-up analysis of 157 women after thrombophilia screening. / Grandone, E.; Villani, M.; Tiscia, G. L.; Dentali, F.; Colaizzo, D.; Cappucci, F.; Chinni, E.; Ageno, W.; Margaglione, M.
In: Thrombosis Research, Vol. 133, No. 2, 02.2014, p. 168-172.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical Pregnancies and Live Births in women approaching ART
T2 - A follow-up analysis of 157 women after thrombophilia screening
AU - Grandone, E.
AU - Villani, M.
AU - Tiscia, G. L.
AU - Dentali, F.
AU - Colaizzo, D.
AU - Cappucci, F.
AU - Chinni, E.
AU - Ageno, W.
AU - Margaglione, M.
PY - 2014/2
Y1 - 2014/2
N2 - Introduction The role of thrombophilia screening and antithrombotic therapy in unselected women undergone Assisted Reproductive Technologies (ART) is largely unknown. Nonetheless, in many Countries infertile women undergo thrombophilia screening and/or antithrombotic therapy. Materials and Methods We carried out a follow-up study. The original sample (n = 1107) consisted of infertile women observed in 13 years. A cohort of 157 women with at least 1 cycle before thrombophilia test and 1 after test was investigated. All underwent thrombophilia screening; an antithrombotic treatment was prescribed in 216 out of 801 cycles. Clinical pregnancy and live birth rates were the main clinical objectives. Results Overall, 15 (9.6%) women carried thrombophilia. The Cox regression showed that LMWH alone or combined with ASA was significantly associated with the outcome "live birth" "live births" (p: 0.015, HR: 2.8, 95%CI: 1.2-6.6 for combined therapy), independently of the carriership of thrombophilia. Women with a lower number of attempts had a higher likelihood of delivering a live-born child using the combined therapy (p <0.001, HR: 0.7, 95%CI: 0.7-0.8), independently of the presence of thrombophilia. Conclusions A potential benefit of LMWH in improving number of live births, independently of the presence of thrombophilia, is suggested. Universal thrombophilia screening before ART is not useful to discriminate women with a worse pregnancy prognosis.
AB - Introduction The role of thrombophilia screening and antithrombotic therapy in unselected women undergone Assisted Reproductive Technologies (ART) is largely unknown. Nonetheless, in many Countries infertile women undergo thrombophilia screening and/or antithrombotic therapy. Materials and Methods We carried out a follow-up study. The original sample (n = 1107) consisted of infertile women observed in 13 years. A cohort of 157 women with at least 1 cycle before thrombophilia test and 1 after test was investigated. All underwent thrombophilia screening; an antithrombotic treatment was prescribed in 216 out of 801 cycles. Clinical pregnancy and live birth rates were the main clinical objectives. Results Overall, 15 (9.6%) women carried thrombophilia. The Cox regression showed that LMWH alone or combined with ASA was significantly associated with the outcome "live birth" "live births" (p: 0.015, HR: 2.8, 95%CI: 1.2-6.6 for combined therapy), independently of the carriership of thrombophilia. Women with a lower number of attempts had a higher likelihood of delivering a live-born child using the combined therapy (p <0.001, HR: 0.7, 95%CI: 0.7-0.8), independently of the presence of thrombophilia. Conclusions A potential benefit of LMWH in improving number of live births, independently of the presence of thrombophilia, is suggested. Universal thrombophilia screening before ART is not useful to discriminate women with a worse pregnancy prognosis.
UR - http://www.scopus.com/inward/record.url?scp=84892368620&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892368620&partnerID=8YFLogxK
U2 - 10.1016/j.thromres.2013.11.016
DO - 10.1016/j.thromres.2013.11.016
M3 - Article
C2 - 24321417
AN - SCOPUS:84892368620
VL - 133
SP - 168
EP - 172
JO - Thrombosis Research
JF - Thrombosis Research
SN - 0049-3848
IS - 2
ER -