Clinical Presentation and Outcome of Brugada Syndrome Diagnosed With the New 2013 Criteria

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Abstract

Introduction: The 2013 HRS/EHRA/APHRS consensus statement recommends the use of V1 and V2 leads recorded in the second and third intercostal spaces (High-ICS) for diagnosis of Brugada syndrome (BrS) creating a new category of patients discovered only with modified leads. The clinical presentation and the arrhythmic risk in these patients are ill defined. This study was aimed at assessing the role of High-ICS in the analysis of BrS and the clinical profile of the patients diagnosed only when ECG leads are moved to upper intercostal spaces. Methods and Results: We searched our Brugada syndrome registry and identified 300 subjects (age 36 ± 13 years), without a diagnostic coved ST-segment elevation in conventional V1–V3 leads, both at baseline and after provocative drug challenge. Sixty-four subjects (21.3%, mean age at last follow-up 42 ± 11 years) were diagnosed with High-ICS. Diagnosis was possible at baseline only in 4 subjects while in 60 it was made after drug challenge with sodium channel blockers. Three subjects (4.7%) with spontaneous abnormal ECG experienced cardiac events with an annual event rate (0.11%) superimposable to that of the low risk category of BrS diagnosed in standard leads. Conclusion: This study demonstrates that the use of new diagnostic criteria for BrS allows increasing the diagnostic yield by 20% and that the arrhythmic risk is low when BrS can be established only in High-ICS. We also show that the prognostic value of spontaneous ECG pattern is confirmed in this subgroup.

Original languageEnglish
Pages (from-to)937-943
Number of pages7
JournalJournal of Cardiovascular Electrophysiology
Volume27
Issue number8
DOIs
Publication statusPublished - 2016

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Brugada Syndrome
Electrocardiography
Sodium Channel Blockers
Pharmaceutical Preparations
Registries

Keywords

  • antiarrhythmic drugs
  • Brugada syndrome
  • genetics
  • risk stratification
  • ST-segment elevation
  • sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

@article{daedb41de6e743b1b7863a3a5e6ad6d9,
title = "Clinical Presentation and Outcome of Brugada Syndrome Diagnosed With the New 2013 Criteria",
abstract = "Introduction: The 2013 HRS/EHRA/APHRS consensus statement recommends the use of V1 and V2 leads recorded in the second and third intercostal spaces (High-ICS) for diagnosis of Brugada syndrome (BrS) creating a new category of patients discovered only with modified leads. The clinical presentation and the arrhythmic risk in these patients are ill defined. This study was aimed at assessing the role of High-ICS in the analysis of BrS and the clinical profile of the patients diagnosed only when ECG leads are moved to upper intercostal spaces. Methods and Results: We searched our Brugada syndrome registry and identified 300 subjects (age 36 ± 13 years), without a diagnostic coved ST-segment elevation in conventional V1–V3 leads, both at baseline and after provocative drug challenge. Sixty-four subjects (21.3{\%}, mean age at last follow-up 42 ± 11 years) were diagnosed with High-ICS. Diagnosis was possible at baseline only in 4 subjects while in 60 it was made after drug challenge with sodium channel blockers. Three subjects (4.7{\%}) with spontaneous abnormal ECG experienced cardiac events with an annual event rate (0.11{\%}) superimposable to that of the low risk category of BrS diagnosed in standard leads. Conclusion: This study demonstrates that the use of new diagnostic criteria for BrS allows increasing the diagnostic yield by 20{\%} and that the arrhythmic risk is low when BrS can be established only in High-ICS. We also show that the prognostic value of spontaneous ECG pattern is confirmed in this subgroup.",
keywords = "antiarrhythmic drugs, Brugada syndrome, genetics, risk stratification, ST-segment elevation, sudden cardiac death",
author = "Antonio Curcio and Andrea Mazzanti and Raffaella Bloise and Nicola Monteforte and Ciro Indolfi and Priori, {Silvia G.} and Carlo Napolitano",
year = "2016",
doi = "10.1111/jce.12997",
language = "English",
volume = "27",
pages = "937--943",
journal = "Journal of Cardiovascular Electrophysiology",
issn = "1045-3873",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Clinical Presentation and Outcome of Brugada Syndrome Diagnosed With the New 2013 Criteria

AU - Curcio, Antonio

AU - Mazzanti, Andrea

AU - Bloise, Raffaella

AU - Monteforte, Nicola

AU - Indolfi, Ciro

AU - Priori, Silvia G.

AU - Napolitano, Carlo

PY - 2016

Y1 - 2016

N2 - Introduction: The 2013 HRS/EHRA/APHRS consensus statement recommends the use of V1 and V2 leads recorded in the second and third intercostal spaces (High-ICS) for diagnosis of Brugada syndrome (BrS) creating a new category of patients discovered only with modified leads. The clinical presentation and the arrhythmic risk in these patients are ill defined. This study was aimed at assessing the role of High-ICS in the analysis of BrS and the clinical profile of the patients diagnosed only when ECG leads are moved to upper intercostal spaces. Methods and Results: We searched our Brugada syndrome registry and identified 300 subjects (age 36 ± 13 years), without a diagnostic coved ST-segment elevation in conventional V1–V3 leads, both at baseline and after provocative drug challenge. Sixty-four subjects (21.3%, mean age at last follow-up 42 ± 11 years) were diagnosed with High-ICS. Diagnosis was possible at baseline only in 4 subjects while in 60 it was made after drug challenge with sodium channel blockers. Three subjects (4.7%) with spontaneous abnormal ECG experienced cardiac events with an annual event rate (0.11%) superimposable to that of the low risk category of BrS diagnosed in standard leads. Conclusion: This study demonstrates that the use of new diagnostic criteria for BrS allows increasing the diagnostic yield by 20% and that the arrhythmic risk is low when BrS can be established only in High-ICS. We also show that the prognostic value of spontaneous ECG pattern is confirmed in this subgroup.

AB - Introduction: The 2013 HRS/EHRA/APHRS consensus statement recommends the use of V1 and V2 leads recorded in the second and third intercostal spaces (High-ICS) for diagnosis of Brugada syndrome (BrS) creating a new category of patients discovered only with modified leads. The clinical presentation and the arrhythmic risk in these patients are ill defined. This study was aimed at assessing the role of High-ICS in the analysis of BrS and the clinical profile of the patients diagnosed only when ECG leads are moved to upper intercostal spaces. Methods and Results: We searched our Brugada syndrome registry and identified 300 subjects (age 36 ± 13 years), without a diagnostic coved ST-segment elevation in conventional V1–V3 leads, both at baseline and after provocative drug challenge. Sixty-four subjects (21.3%, mean age at last follow-up 42 ± 11 years) were diagnosed with High-ICS. Diagnosis was possible at baseline only in 4 subjects while in 60 it was made after drug challenge with sodium channel blockers. Three subjects (4.7%) with spontaneous abnormal ECG experienced cardiac events with an annual event rate (0.11%) superimposable to that of the low risk category of BrS diagnosed in standard leads. Conclusion: This study demonstrates that the use of new diagnostic criteria for BrS allows increasing the diagnostic yield by 20% and that the arrhythmic risk is low when BrS can be established only in High-ICS. We also show that the prognostic value of spontaneous ECG pattern is confirmed in this subgroup.

KW - antiarrhythmic drugs

KW - Brugada syndrome

KW - genetics

KW - risk stratification

KW - ST-segment elevation

KW - sudden cardiac death

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DO - 10.1111/jce.12997

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