Clinical presentation and outcome of non-AIDS defining cancers, in HIV-infected patients in the ART-era: The Italian cooperative group on AIDS and tumors activity

M. Berretta, F. Martellotta, R. Di Francia, M. Spina, E. Vaccher, L. Balestreri, E. Borsatti, A. Bearz, P. De Paoli, U. Tirelli

Research output: Contribution to journalArticle

Abstract

The advent of antiretroviral therapy (ART) has markedly extended the survival rates of patients with human immunodeficiency virus (HIV), leading to suppression even though not eradication of HIV. In HIV infected patients, cancer has become a growing problem, representing the first cause of death. A large number of worldwide studies have shown that HIV infection raises the risk of many non-AIDS defining cancers (NADCs), including squamous cell carcinoma of the anus (SCCA), testis cancer, lung cancer, cancer of the colon and rectum (CRC), skin (basal cell skin carcinoma and melanoma), Hodgkin disease (HD) and hepatocellular carcinoma (HCC). Generally in HIV positive patients NADCs are more aggressive and in advanced stage disease than in the general population. In the ART era, however, the outcome of HIV positive patients is more similar as in the general population. Only about lung cancer the outcome seems different between HIV positive and HIV negative patients. The aim of this article is to provide an update on NADCs within the activity of the Italian Cooperative Group on AIDS and Tumors (GICAT) to identify clinical prognostic and predicting factors in patients with HIV infection included in the GICAT.

Original languageEnglish
Pages (from-to)3619-3634
Number of pages16
JournalEuropean Review for Medical and Pharmacological Sciences
Volume19
Issue number19
Publication statusPublished - 2015

Keywords

  • Cancer
  • Chemotherapy
  • Clinical aspects
  • HIV
  • NADCs
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Clinical presentation and outcome of non-AIDS defining cancers, in HIV-infected patients in the ART-era: The Italian cooperative group on AIDS and tumors activity'. Together they form a unique fingerprint.

  • Cite this