Clinical presentation of Attenuated Psychosis Syndrome in children and adolescents: Is there an age effect?

Michele Ribolsi, Ashleigh Lin, Klaas J. Wardenaar, Maria Pontillo, Luigi Mazzone, Stefano Vicari, Marco Armando

Research output: Contribution to journalArticle

Abstract

There is limited research on clinical features related to age of presentation of the Attenuated Psychosis Syndrome in children and adolescents (CAD). Based on findings in CAD with psychosis, we hypothesized that an older age at presentation of Attenuated Psychosis Syndrome would be associated with less severe symptoms and better psychosocial functioning than presentation in childhood or younger adolescence. Ninety-four CAD (age 9–18) meeting Attenuated Psychosis Syndrome criteria participated in the study. The sample was divided and compared according to the age of presentation of Attenuated Psychosis Syndrome (9–14 vs 15–18 years). The predictive value of age of Attenuated Psychosis Syndrome presentation was investigated using receiver operating characteristic (ROC)-curve calculations. The two Attenuated Psychosis Syndrome groups were homogeneous in terms of gender distribution, IQ scores and comorbid diagnoses. Older Attenuated Psychosis Syndrome patients showed better functioning and lower depressive scores. ROC curves revealed that severity of functional impairment was best predicted using an age of presentation cut-off of 14.9 years for social functioning and 15.9 years for role functioning. This study partially confirmed our hypothesis; older age at presentation of Attenuated Psychosis Syndrome was associated with less functional impairment, but age was not associated with psychotic symptoms.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalPsychiatry Research
Volume252
DOIs
Publication statusPublished - Jun 1 2017

Keywords

  • Adolescents
  • Attenuated psychosis syndrome
  • Children
  • Functioning
  • Psychosocial
  • Psychotic symptoms
  • Ultra high risk

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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