Clinical profile of Ioversol a metaanalysis of 57 randomized, double- blind clinical trials

Irene Floriani, M. Ciceri, V. Torri, A. Tinazzi, H. Jahn, A. Noseda

Research output: Contribution to journalArticle

Abstract

RATIONALE AND OBJECTIVES. The authors characterize the clinical profile of ioversol, specifically in terms of radiographic efficacy and clinical tolerance. METHODS. Metaanalysis of data from all available randomized, double-blind trials, comparing ioversol with other nonionic contrast media in indicated procedures was conducted. A total of 3854 adult patients were studied (1931 ioversol, 1923 reference) from 57 clinical trials. RESULTS. Ioversol was considered diagnostic in 99.3% of examinations, with good to excellent enhancement quality in 89.3% of cases. In comparative evaluations, there was a 24% odds reduction of the investigator's nondiagnostic judgment and a 15% odds reduction of poor to fair quality in favor of ioversol. For tolerance, 20.2% and 3.3% of patients in the ioversol group reported moderate to severe sensation of heat and pain with a 10% odds reduction and a 3% odds increase, respectively. The incidence of drug-related adverse events was low: 76 (3.3%) patients in the ioversol group and 62 (2.9%) patients in control group. No statistically significant differences were noted. CONCLUSION. Based on these findings, the high-contrast efficacy and patient tolerance make ioversol a suitable agent, equivalent to other nonionic contrast media.

Original languageEnglish
Pages (from-to)479-491
Number of pages13
JournalInvestigative Radiology
Volume31
Issue number8
DOIs
Publication statusPublished - Aug 1996

Keywords

  • Ioversol
  • metaanalysis
  • nonionic contrast media

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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