TY - JOUR
T1 - Clinical proton MR spectroscopy in central nervous system disorders
AU - Öz, Gülin
AU - Alger, Jeffry R.
AU - Barker, Peter B.
AU - Bartha, Robert
AU - Bizzi, Alberto
AU - Boesch, Chris
AU - Bolan, Patrick J.
AU - Brindle, Kevin M.
AU - Cudalbu, Cristina
AU - Dinçer, Alp
AU - Dydak, Ulrike
AU - Emir, Uzay E.
AU - Frahm, Jens
AU - Gilberto González, Ramón
AU - Gruber, Stephan
AU - Gruetter, Rolf
AU - Gupta, Rakesh K.
AU - Heerschap, Arend
AU - Henning, Anke
AU - Hetherington, Hoby P.
AU - Howe, Franklyn A.
AU - Hüppi, Petra S.
AU - Hurd, Ralph E.
PY - 2014
Y1 - 2014
N2 - A large body of published work shows that proton (hydrogen 1 [ 1H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectroscopy has an impact on patient management, together with a critical consideration of common data acquisition and processing procedures. The article documents the impact of 1H MR spectroscopy in the clinical evaluation of disorders of the central nervous system. The clinical usefulness of 1H MR spectroscopy has been established for brain neoplasms, neonatal and pediatric disorders (hypoxia-ischemia, inherited metabolic diseases, and traumatic brain injury), demyelinating disorders, and infectious brain lesions. The growing list of disorders for which 1H MR spectroscopy may contribute to patient management extends to neurodegenerative diseases, epilepsy, and stroke. To facilitate expanded clinical acceptance and standardization of MR spectroscopy methodology, guidelines are provided for data acquisition and analysis, quality assessment, and interpretation. Finally, the authors offer recommendations to expedite the use of robust MR spectroscopy methodology in the clinical setting, including incorporation of technical advances on clinical units.
AB - A large body of published work shows that proton (hydrogen 1 [ 1H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectroscopy has an impact on patient management, together with a critical consideration of common data acquisition and processing procedures. The article documents the impact of 1H MR spectroscopy in the clinical evaluation of disorders of the central nervous system. The clinical usefulness of 1H MR spectroscopy has been established for brain neoplasms, neonatal and pediatric disorders (hypoxia-ischemia, inherited metabolic diseases, and traumatic brain injury), demyelinating disorders, and infectious brain lesions. The growing list of disorders for which 1H MR spectroscopy may contribute to patient management extends to neurodegenerative diseases, epilepsy, and stroke. To facilitate expanded clinical acceptance and standardization of MR spectroscopy methodology, guidelines are provided for data acquisition and analysis, quality assessment, and interpretation. Finally, the authors offer recommendations to expedite the use of robust MR spectroscopy methodology in the clinical setting, including incorporation of technical advances on clinical units.
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U2 - 10.1148/radiol.13130531
DO - 10.1148/radiol.13130531
M3 - Article
C2 - 24568703
AN - SCOPUS:84895440282
VL - 270
SP - 658
EP - 679
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 3
ER -