Clinical Reasoning: A 75-year-old man with parkinsonism, mood depression, and weight loss

Emanuele Frattini, Edoardo Monfrini, Giacomo Bitetto, Barbara Ferrari, Sara Arcudi, Nereo Bresolin, Maria Cristina Saetti, Alessio Di Fonzo

Research output: Contribution to journalArticle

Abstract

A 75-year-old man presented to the emergency department with a 1-year history of 66-pound weight loss and alternating bowel habits. He was admitted to the hospital, where he underwent several examinations to investigate the presence of a malignancy. A colonoscopy, a gastroscopy, an ultrasound of the abdomen, and a contrast-enhanced CT scan of thorax and abdomen did not detect any neoplasia. The only findings consisted of a prostatic hypertrophy and a basal pleural-parenchymal hyperdensity in the left lung, which was described as the result of an infective process. Neoplastic markers CA19.9, carcinoembryonic antigen, neuron-specific enolase, and α-fetoprotein were also negative. Wide-spectrum blood tests were unremarkable, except for hypogammaglobulinemia and elevated β2 microglobulin.

Original languageEnglish
Pages (from-to)572-575
Number of pages4
JournalNeurology
Volume90
Issue number12
DOIs
Publication statusPublished - Mar 20 2018

ASJC Scopus subject areas

  • Clinical Neurology

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