Clinical relevance of a polymorphism within the ihterleukin-lβ (IL-Lβ) promoter in patients with multiple sclerosis

C. Meoni, V. Caiadei, M. Marroiu, D. Franciotta, M. Zaffaroni, Lue Grimaldi

Research output: Contribution to journalArticle

Abstract

Cytokines are essential in orchestrating autoimmune inflammatory phenomena typical of multiple sclerosis (MSI , a polygenic demyelinating disease of the CNS. As most cytokines, IL-l, the prototypical proinflammatory cytokine, is polymorphic. We evaluated the clinical relevance of a restriction polymorphism of its promoter, resulting in two alleles (Al and A2), in 352 MS patients (146 Caucasians and 206 Sardinians) and 210 healthy controls (HC) (126 Caucasians and 82 Sardinians). Genotype frequencies were similar between MS groups and healthy controls (HC). When analysing possible influences of the Al allele on clinical features of MS, we found Al significantly ana positively ässociuLeu wich lelapsing-iemiLt-uy (RR) vs. primary progressive (p10 years and EDSS £3) vs. non benign MS (p10 years indicated a -direct correlation between Al CR and EDSS (p

Original languageEnglish
Pages (from-to)78
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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