Clinical relevance of polymorphic markers of arterial thrombosis

Giovanni Di Minno, Elvira Grandone, Maurizio Margaglione

Research output: Contribution to journalArticle

Abstract

Case-control and cross-sectional studies show that some common molecular variations (polymorphisms) of genes coding for proteins involved in atherosclerosis and thrombosis are often present in subjects who have experienced cerebrovascular or cardiovascular events. The clinical impact of the majority of polymorphic markers is disputed by prospective reports. In contrast, their pathophysiological implications and their role in monitoring parameters that are difficult to be checked by alternative means, are documented by the large majority of the reports. From the evidence available, there may be suggestion for further impact of polymorphic markers in vascular medicine. To substantiate this, new prospective studies that include individuals from different geographical areas and that take into account the statistical power, the informativeness of the markers, the coexistance of established risk factors and the genetic backgroud of the populations analyzed, are urgently needed.

Original languageEnglish
Pages (from-to)462-466
Number of pages5
JournalThrombosis and Haemostasis
Volume78
Issue number1
Publication statusPublished - Jul 1997

Fingerprint

Population Genetics
Cardiology
Atherosclerosis
Thrombosis
Cross-Sectional Studies
Prospective Studies
Proteins

ASJC Scopus subject areas

  • Hematology

Cite this

Clinical relevance of polymorphic markers of arterial thrombosis. / Di Minno, Giovanni; Grandone, Elvira; Margaglione, Maurizio.

In: Thrombosis and Haemostasis, Vol. 78, No. 1, 07.1997, p. 462-466.

Research output: Contribution to journalArticle

Di Minno, G, Grandone, E & Margaglione, M 1997, 'Clinical relevance of polymorphic markers of arterial thrombosis', Thrombosis and Haemostasis, vol. 78, no. 1, pp. 462-466.
Di Minno, Giovanni ; Grandone, Elvira ; Margaglione, Maurizio. / Clinical relevance of polymorphic markers of arterial thrombosis. In: Thrombosis and Haemostasis. 1997 ; Vol. 78, No. 1. pp. 462-466.
@article{214654b8fb6d4163a339e1b06b854cba,
title = "Clinical relevance of polymorphic markers of arterial thrombosis",
abstract = "Case-control and cross-sectional studies show that some common molecular variations (polymorphisms) of genes coding for proteins involved in atherosclerosis and thrombosis are often present in subjects who have experienced cerebrovascular or cardiovascular events. The clinical impact of the majority of polymorphic markers is disputed by prospective reports. In contrast, their pathophysiological implications and their role in monitoring parameters that are difficult to be checked by alternative means, are documented by the large majority of the reports. From the evidence available, there may be suggestion for further impact of polymorphic markers in vascular medicine. To substantiate this, new prospective studies that include individuals from different geographical areas and that take into account the statistical power, the informativeness of the markers, the coexistance of established risk factors and the genetic backgroud of the populations analyzed, are urgently needed.",
author = "{Di Minno}, Giovanni and Elvira Grandone and Maurizio Margaglione",
year = "1997",
month = "7",
language = "English",
volume = "78",
pages = "462--466",
journal = "Thrombosis and Haemostasis",
issn = "0340-6245",
publisher = "Schattauer GmbH",
number = "1",

}

TY - JOUR

T1 - Clinical relevance of polymorphic markers of arterial thrombosis

AU - Di Minno, Giovanni

AU - Grandone, Elvira

AU - Margaglione, Maurizio

PY - 1997/7

Y1 - 1997/7

N2 - Case-control and cross-sectional studies show that some common molecular variations (polymorphisms) of genes coding for proteins involved in atherosclerosis and thrombosis are often present in subjects who have experienced cerebrovascular or cardiovascular events. The clinical impact of the majority of polymorphic markers is disputed by prospective reports. In contrast, their pathophysiological implications and their role in monitoring parameters that are difficult to be checked by alternative means, are documented by the large majority of the reports. From the evidence available, there may be suggestion for further impact of polymorphic markers in vascular medicine. To substantiate this, new prospective studies that include individuals from different geographical areas and that take into account the statistical power, the informativeness of the markers, the coexistance of established risk factors and the genetic backgroud of the populations analyzed, are urgently needed.

AB - Case-control and cross-sectional studies show that some common molecular variations (polymorphisms) of genes coding for proteins involved in atherosclerosis and thrombosis are often present in subjects who have experienced cerebrovascular or cardiovascular events. The clinical impact of the majority of polymorphic markers is disputed by prospective reports. In contrast, their pathophysiological implications and their role in monitoring parameters that are difficult to be checked by alternative means, are documented by the large majority of the reports. From the evidence available, there may be suggestion for further impact of polymorphic markers in vascular medicine. To substantiate this, new prospective studies that include individuals from different geographical areas and that take into account the statistical power, the informativeness of the markers, the coexistance of established risk factors and the genetic backgroud of the populations analyzed, are urgently needed.

UR - http://www.scopus.com/inward/record.url?scp=0030809467&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030809467&partnerID=8YFLogxK

M3 - Article

C2 - 9198197

AN - SCOPUS:0030809467

VL - 78

SP - 462

EP - 466

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

IS - 1

ER -