Abstract
Case-control and cross-sectional studies show that some common molecular variations (polymorphisms) of genes coding for proteins involved in atherosclerosis and thrombosis are often present in subjects who have experienced cerebrovascular or cardiovascular events. The clinical impact of the majority of polymorphic markers is disputed by prospective reports. In contrast, their pathophysiological implications and their role in monitoring parameters that are difficult to be checked by alternative means, are documented by the large majority of the reports. From the evidence available, there may be suggestion for further impact of polymorphic markers in vascular medicine. To substantiate this, new prospective studies that include individuals from different geographical areas and that take into account the statistical power, the informativeness of the markers, the coexistance of established risk factors and the genetic backgroud of the populations analyzed, are urgently needed.
| Original language | English |
|---|---|
| Pages (from-to) | 462-466 |
| Number of pages | 5 |
| Journal | Thrombosis and Haemostasis |
| Volume | 78 |
| Issue number | 1 |
| Publication status | Published - Jul 1997 |
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ASJC Scopus subject areas
- Hematology
Cite this
Clinical relevance of polymorphic markers of arterial thrombosis. / Di Minno, Giovanni; Grandone, Elvira; Margaglione, Maurizio.
In: Thrombosis and Haemostasis, Vol. 78, No. 1, 07.1997, p. 462-466.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical relevance of polymorphic markers of arterial thrombosis
AU - Di Minno, Giovanni
AU - Grandone, Elvira
AU - Margaglione, Maurizio
PY - 1997/7
Y1 - 1997/7
N2 - Case-control and cross-sectional studies show that some common molecular variations (polymorphisms) of genes coding for proteins involved in atherosclerosis and thrombosis are often present in subjects who have experienced cerebrovascular or cardiovascular events. The clinical impact of the majority of polymorphic markers is disputed by prospective reports. In contrast, their pathophysiological implications and their role in monitoring parameters that are difficult to be checked by alternative means, are documented by the large majority of the reports. From the evidence available, there may be suggestion for further impact of polymorphic markers in vascular medicine. To substantiate this, new prospective studies that include individuals from different geographical areas and that take into account the statistical power, the informativeness of the markers, the coexistance of established risk factors and the genetic backgroud of the populations analyzed, are urgently needed.
AB - Case-control and cross-sectional studies show that some common molecular variations (polymorphisms) of genes coding for proteins involved in atherosclerosis and thrombosis are often present in subjects who have experienced cerebrovascular or cardiovascular events. The clinical impact of the majority of polymorphic markers is disputed by prospective reports. In contrast, their pathophysiological implications and their role in monitoring parameters that are difficult to be checked by alternative means, are documented by the large majority of the reports. From the evidence available, there may be suggestion for further impact of polymorphic markers in vascular medicine. To substantiate this, new prospective studies that include individuals from different geographical areas and that take into account the statistical power, the informativeness of the markers, the coexistance of established risk factors and the genetic backgroud of the populations analyzed, are urgently needed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0030809467&partnerID=8YFLogxK
M3 - Article
C2 - 9198197
AN - SCOPUS:0030809467
VL - 78
SP - 462
EP - 466
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 1
ER -