Clinical relevance of polymorphic markers of arterial thrombosis

Giovanni Di Minno, Elvira Grandone, Maurizio Margaglione

Research output: Contribution to journalArticlepeer-review


Case-control and cross-sectional studies show that some common molecular variations (polymorphisms) of genes coding for proteins involved in atherosclerosis and thrombosis are often present in subjects who have experienced cerebrovascular or cardiovascular events. The clinical impact of the majority of polymorphic markers is disputed by prospective reports. In contrast, their pathophysiological implications and their role in monitoring parameters that are difficult to be checked by alternative means, are documented by the large majority of the reports. From the evidence available, there may be suggestion for further impact of polymorphic markers in vascular medicine. To substantiate this, new prospective studies that include individuals from different geographical areas and that take into account the statistical power, the informativeness of the markers, the coexistance of established risk factors and the genetic backgroud of the populations analyzed, are urgently needed.

Original languageEnglish
Pages (from-to)462-466
Number of pages5
JournalThrombosis and Haemostasis
Issue number1
Publication statusPublished - Jul 1997

ASJC Scopus subject areas

  • Hematology

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