Clinical Relevance of Subcentimetric Lymph Node Biopsy in the Diagnosis of Ocular Sarcoidosis

Elena Bolletta; Valentina Mastrofilippo; Alessandro Invernizzi; Raffaella Aldigeri; Lucia Spaggiari; Giulia Besutti; Roberto Borrelli; Filippo Lo Coco; Tommaso Ricchetti; Cristian Rapicetta; Alberto Cavazza; Giovanni Musci; Luca De Simone; Fabrizio Gozzi; Carlo Salvarani; Nicolò Pipitone; Massimiliano Paci; Luca Cimino

doi:10.1080/09273948.2020.1817503

Clinical Relevance of Subcentimetric Lymph Node Biopsy in the Diagnosis of Ocular Sarcoidosis

Elena Bolletta, Valentina Mastrofilippo, Alessandro Invernizzi, Raffaella Aldigeri, Lucia Spaggiari, Giulia Besutti, Roberto Borrelli, Filippo Lo Coco, Tommaso Ricchetti, Cristian Rapicetta, Alberto Cavazza, Giovanni Musci, Luca De Simone, Fabrizio Gozzi, Carlo Salvarani, Nicolò Pipitone, Massimiliano Paci, Luca Cimino

Arcispedale Santa Maria Nuova

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To evaluate the clinical relevance of subcentimetric lymph node biopsy via mediastinoscopy in patients with presumed ocular sarcoidosis (OS). Methods: Retrospective study of consecutive patients who underwent biopsy via mediastinoscopy for suspected OS. The biopsy outcomes and clinical features of patients with subcentimetric nodes and of those with lymph nodes >1 cm were compared. Results: A total of 67 patients with presumed OS were included. Forty-two patients (63%) had lymph nodes ≥1 cm in diameter, while 25(37%) showed subcentimetric lymph nodes. Biopsy was consistent with sarcoidosis in 83% of patients with lymph nodes ≥1 cm and in 76% of patients with subcentimetric lymph nodes (p = .60). Patients with OS who had subcentimetric lymph nodes had less lymphopenia (p = .01), lower lysozyme values (p = .03) and a longer diagnostic delay compared to those with larger lymph nodes. Conclusions: The biopsy of subcentimetric lymph nodes via mediastinoscopy may provide a histological diagnosis and reduce diagnostic delay.

Original language	English
Journal	Ocular Immunology and Inflammation
DOIs	https://doi.org/10.1080/09273948.2020.1817503
Publication status	Accepted/In press - 2020

Keywords

biopsy
mediastinoscopy
Ocular sarcoidosis
sarcoid uveitis

ASJC Scopus subject areas

Immunology and Allergy
Ophthalmology

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10.1080/09273948.2020.1817503

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Bolletta, E., Mastrofilippo, V., Invernizzi, A., Aldigeri, R., Spaggiari, L., Besutti, G., Borrelli, R., Lo Coco, F., Ricchetti, T., Rapicetta, C., Cavazza, A., Musci, G., De Simone, L., Gozzi, F., Salvarani, C., Pipitone, N., Paci, M., & Cimino, L. (Accepted/In press). Clinical Relevance of Subcentimetric Lymph Node Biopsy in the Diagnosis of Ocular Sarcoidosis. Ocular Immunology and Inflammation. https://doi.org/10.1080/09273948.2020.1817503

Bolletta, E, Mastrofilippo, V, Invernizzi, A, Aldigeri, R, Spaggiari, L, Besutti, G, Borrelli, R, Lo Coco, F, Ricchetti, T, Rapicetta, C , Cavazza, A, Musci, G, De Simone, L, Gozzi, F, Salvarani, C, Pipitone, N, Paci, M & Cimino, L 2020, 'Clinical Relevance of Subcentimetric Lymph Node Biopsy in the Diagnosis of Ocular Sarcoidosis', Ocular Immunology and Inflammation. https://doi.org/10.1080/09273948.2020.1817503

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abstract = "Purpose: To evaluate the clinical relevance of subcentimetric lymph node biopsy via mediastinoscopy in patients with presumed ocular sarcoidosis (OS). Methods: Retrospective study of consecutive patients who underwent biopsy via mediastinoscopy for suspected OS. The biopsy outcomes and clinical features of patients with subcentimetric nodes and of those with lymph nodes >1 cm were compared. Results: A total of 67 patients with presumed OS were included. Forty-two patients (63%) had lymph nodes ≥1 cm in diameter, while 25(37%) showed subcentimetric lymph nodes. Biopsy was consistent with sarcoidosis in 83% of patients with lymph nodes ≥1 cm and in 76% of patients with subcentimetric lymph nodes (p = .60). Patients with OS who had subcentimetric lymph nodes had less lymphopenia (p = .01), lower lysozyme values (p = .03) and a longer diagnostic delay compared to those with larger lymph nodes. Conclusions: The biopsy of subcentimetric lymph nodes via mediastinoscopy may provide a histological diagnosis and reduce diagnostic delay.",

keywords = "biopsy, mediastinoscopy, Ocular sarcoidosis, sarcoid uveitis",

author = "Elena Bolletta and Valentina Mastrofilippo and Alessandro Invernizzi and Raffaella Aldigeri and Lucia Spaggiari and Giulia Besutti and Roberto Borrelli and {Lo Coco}, Filippo and Tommaso Ricchetti and Cristian Rapicetta and Alberto Cavazza and Giovanni Musci and {De Simone}, Luca and Fabrizio Gozzi and Carlo Salvarani and Nicol{\`o} Pipitone and Massimiliano Paci and Luca Cimino",

year = "2020",

doi = "10.1080/09273948.2020.1817503",

language = "English",

journal = "Ocular Immunology and Inflammation",

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TY - JOUR

T1 - Clinical Relevance of Subcentimetric Lymph Node Biopsy in the Diagnosis of Ocular Sarcoidosis

AU - Bolletta, Elena

AU - Mastrofilippo, Valentina

AU - Invernizzi, Alessandro

AU - Aldigeri, Raffaella

AU - Spaggiari, Lucia

AU - Besutti, Giulia

AU - Borrelli, Roberto

AU - Lo Coco, Filippo

AU - Ricchetti, Tommaso

AU - Rapicetta, Cristian

AU - Cavazza, Alberto

AU - Musci, Giovanni

AU - De Simone, Luca

AU - Gozzi, Fabrizio

AU - Salvarani, Carlo

AU - Pipitone, Nicolò

AU - Paci, Massimiliano

AU - Cimino, Luca

PY - 2020

Y1 - 2020

N2 - Purpose: To evaluate the clinical relevance of subcentimetric lymph node biopsy via mediastinoscopy in patients with presumed ocular sarcoidosis (OS). Methods: Retrospective study of consecutive patients who underwent biopsy via mediastinoscopy for suspected OS. The biopsy outcomes and clinical features of patients with subcentimetric nodes and of those with lymph nodes >1 cm were compared. Results: A total of 67 patients with presumed OS were included. Forty-two patients (63%) had lymph nodes ≥1 cm in diameter, while 25(37%) showed subcentimetric lymph nodes. Biopsy was consistent with sarcoidosis in 83% of patients with lymph nodes ≥1 cm and in 76% of patients with subcentimetric lymph nodes (p = .60). Patients with OS who had subcentimetric lymph nodes had less lymphopenia (p = .01), lower lysozyme values (p = .03) and a longer diagnostic delay compared to those with larger lymph nodes. Conclusions: The biopsy of subcentimetric lymph nodes via mediastinoscopy may provide a histological diagnosis and reduce diagnostic delay.

AB - Purpose: To evaluate the clinical relevance of subcentimetric lymph node biopsy via mediastinoscopy in patients with presumed ocular sarcoidosis (OS). Methods: Retrospective study of consecutive patients who underwent biopsy via mediastinoscopy for suspected OS. The biopsy outcomes and clinical features of patients with subcentimetric nodes and of those with lymph nodes >1 cm were compared. Results: A total of 67 patients with presumed OS were included. Forty-two patients (63%) had lymph nodes ≥1 cm in diameter, while 25(37%) showed subcentimetric lymph nodes. Biopsy was consistent with sarcoidosis in 83% of patients with lymph nodes ≥1 cm and in 76% of patients with subcentimetric lymph nodes (p = .60). Patients with OS who had subcentimetric lymph nodes had less lymphopenia (p = .01), lower lysozyme values (p = .03) and a longer diagnostic delay compared to those with larger lymph nodes. Conclusions: The biopsy of subcentimetric lymph nodes via mediastinoscopy may provide a histological diagnosis and reduce diagnostic delay.

KW - biopsy

KW - mediastinoscopy

KW - Ocular sarcoidosis

KW - sarcoid uveitis

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Clinical Relevance of Subcentimetric Lymph Node Biopsy in the Diagnosis of Ocular Sarcoidosis

Abstract

Keywords

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