Clinical relevance of two in vitro tests based on CFU-GM assay in the study of granulopoietic failure

C. C. Stella; A. Ghizzi; P. Pedrazzoli

Clinical relevance of two in vitro tests based on CFU-GM assay in the study of granulopoietic failure

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Abstract

In 18 patients with granulopoietic failure we studied marrow CFU-GM growth according to Pike and Robinson's technique. In order to detect marrow cells inhibiting granulopoiesis we assayed CFU-GM growth after antilymphocyte globulin (ALG) pretreatment of marrow cells; in order to detect the ability of peripheral blood mononuclear leukocytes (PBML) to suppress CFU-GM proliferation we studied CFU-GM growth in coculture with PBML. In 5 of 18 patients ALG pretreatment significantly enhanced cluster (p

Original language	English
Pages (from-to)	487-494
Number of pages	8
Journal	Haematologica
Volume	70
Issue number	6
Publication status	Published - 1985

ASJC Scopus subject areas

Hematology

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title = "Clinical relevance of two in vitro tests based on CFU-GM assay in the study of granulopoietic failure",

abstract = "In 18 patients with granulopoietic failure we studied marrow CFU-GM growth according to Pike and Robinson's technique. In order to detect marrow cells inhibiting granulopoiesis we assayed CFU-GM growth after antilymphocyte globulin (ALG) pretreatment of marrow cells; in order to detect the ability of peripheral blood mononuclear leukocytes (PBML) to suppress CFU-GM proliferation we studied CFU-GM growth in coculture with PBML. In 5 of 18 patients ALG pretreatment significantly enhanced cluster (p",

author = "Stella, {C. C.} and A. Ghizzi and P. Pedrazzoli",

year = "1985",

language = "English",

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journal = "Haematologica",

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AU - Stella, C. C.

AU - Ghizzi, A.

AU - Pedrazzoli, P.

PY - 1985

Y1 - 1985

N2 - In 18 patients with granulopoietic failure we studied marrow CFU-GM growth according to Pike and Robinson's technique. In order to detect marrow cells inhibiting granulopoiesis we assayed CFU-GM growth after antilymphocyte globulin (ALG) pretreatment of marrow cells; in order to detect the ability of peripheral blood mononuclear leukocytes (PBML) to suppress CFU-GM proliferation we studied CFU-GM growth in coculture with PBML. In 5 of 18 patients ALG pretreatment significantly enhanced cluster (p

AB - In 18 patients with granulopoietic failure we studied marrow CFU-GM growth according to Pike and Robinson's technique. In order to detect marrow cells inhibiting granulopoiesis we assayed CFU-GM growth after antilymphocyte globulin (ALG) pretreatment of marrow cells; in order to detect the ability of peripheral blood mononuclear leukocytes (PBML) to suppress CFU-GM proliferation we studied CFU-GM growth in coculture with PBML. In 5 of 18 patients ALG pretreatment significantly enhanced cluster (p

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ER -

Clinical relevance of two in vitro tests based on CFU-GM assay in the study of granulopoietic failure

Abstract

ASJC Scopus subject areas

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