Clinical relevance of two in vitro tests based on CFU-GM assay in the study of granulopoietic failure

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Abstract

In 18 patients with granulopoietic failure we studied marrow CFU-GM growth according to Pike and Robinson's technique. In order to detect marrow cells inhibiting granulopoiesis we assayed CFU-GM growth after antilymphocyte globulin (ALG) pretreatment of marrow cells; in order to detect the ability of peripheral blood mononuclear leukocytes (PBML) to suppress CFU-GM proliferation we studied CFU-GM growth in coculture with PBML. In 5 of 18 patients ALG pretreatment significantly enhanced cluster (p

Original languageEnglish
Pages (from-to)487-494
Number of pages8
JournalHaematologica
Volume70
Issue number6
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Hematology

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