Clinical response to tDCS depends on residual brain metabolism and grey matter integrity in patients with minimally conscious state

Aurore Thibaut, Carol Di Perri, Camille Chatelle, Marie Aurélie Bruno, Mohamed Ali Bahri, Sarah Wannez, Andrea Piarulli, Claire Bernard, Charlotte Martial, Lizette Heine, Roland Hustinx, Steven Laureys

Research output: Contribution to journalArticlepeer-review

Abstract

Background Transcranial direct current stimulation (tDCS) was recently shown to promote recovery of voluntary signs of consciousness in some patients in minimally conscious state (MCS). However, it remains unclear why clinical improvement is only observed in a subgroup of patients. Objectives In this retrospective study, we investigated the relationship between tDCS responsiveness and neuroimaging data from MCS patients. Methods Structural Magnetic Resonance Imaging (MRI), Fluorodeoxyglucose Positron emission tomography (FDG-PET) and clinical electroencephalography (EEG) were acquired in 21 sub-acute and chronic MCS patients (8 tDCS responders) who subsequently (

Original languageEnglish
Pages (from-to)1116-1123
Number of pages8
JournalBrain Stimulation
Volume8
Issue number6
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • Disorders of consciousness
  • Magnetic resonance imaging
  • Minimally conscious state
  • Positron emission tomography
  • Transcranial direct current stimulation
  • Treatment
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Biophysics

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