Clinical review of 247 case records of spitz nevus (epithelioid cell and/or spindle cell nevus)

V. Dal Pozzo, C. Benelli, L. Restano, R. Gianotti, B. M. Cesana

Research output: Contribution to journalArticlepeer-review


Background: Spitz nevus has clinically been described as a dome-shaped usually nonpigmented papular or nodular lesion variable in color from pink to red. Objectives: To give an exhaustive description of the clinical features of the Spitz nevus from a large series of 247 patients. Methods: A retrospective analysis of the clinical features of 247 Spitz nevi excised from 1974 to 1993 has been performed. We evaluated the following features: age, sex, anatomical location, clinical and histopathologic features; descriptive statistics were calculated and relationships among the above variables were assessed. Results: Most lesions were pigmented (71.7%), located on the lower extremities (43.3%), more frequent in the first decade (55.8%) and in females (57.9%). The nonpigmented type was more frequent in the head or neck region, whereas the pigmented types were more frequent on the lower extremities. Besides, these types showed different histopathologic features: the spindle cells usually predominated in the flat pigmented type, whereas dome-shaped types were usually composed of both spindle and epithelioid cells. Conclusions: In our patients, the pigmented Spitz nevi were more common than the nonpigmented ones; furthermore pigmented and nonpigmented Spitz nevi showed different anatomical locations and different histopathologic features.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
Issue number1
Publication statusPublished - 1997


  • Epithelioid cell nevus
  • Spindle cell nevus
  • Spitz nevus

ASJC Scopus subject areas

  • Dermatology


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