Clinical significance of atrophy and white matter mean diffusivity within the thalamus of multiple sclerosis patients

Ralph H B Benedict, Hanneke E. Hulst, Niels Bergsland, Menno M. Schoonheim, Michael G. Dwyer, Bianca Weinstock-Guttman, Jeroen J G Geurts, Robert Zivadinov

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Gray-matter (GM) atrophy is strongly predictive of cognitive impairment in multiple sclerosis (MS) patients. The thalamus is the region where the atrophy/cognition correlation is most robust. However, few studies have assessed diffusion tensor imaging (DTI) metrics within the thalamus. Objective: This study was designed to determine if thalamus white matter DTI predicts cognitive impairment after accounting for the effects of volume loss. Methods: We enrolled 75 MS patients and 18 healthy controls undergoing 3T brain magnetic resonance imaging (MRI). Thalamus volumes were calculated on 3D T1 images. Voxelwise analyses of DTI metrics were performed within the thalamic white matter tracts. Neuropsychological (NP) testing, acquired using consensus standard methods, contributed measures of memory, cognitive processing speed and executive function. Results: All cognitive tests were significantly predicted (R2 =0.31, p

Original languageEnglish
Pages (from-to)1478-1484
Number of pages7
JournalMultiple Sclerosis Journal
Volume19
Issue number11
DOIs
Publication statusPublished - 2013

Keywords

  • cognitive impairment
  • diffusion tensor imaging
  • mean diffusivity
  • Multiple sclerosis
  • thalamus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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