Clinical significance of bax/bcl-2 ratio in chronic lymphocytic leukemia

Maria Ilaria Del Principe; Michele Dal Bo; Tamara Bittolo; Francesco Buccisano; Francesca Maria Rossi; Antonella Zucchetto; Davide Rossi; Riccardo Bomben; Luca Maurillo; Mariagiovanna Cefalo; Giovanna De Santis; Adriano Venditti; Gianluca Gaidano; Sergio Amadori; Paolo de Fabritiis; Valter Gattei; Giovanni Del Poeta

doi:10.3324/haematol.2015.131854

Clinical significance of bax/bcl-2 ratio in chronic lymphocytic leukemia

Maria Ilaria Del Principe, Michele Dal Bo, Tamara Bittolo, Francesco Buccisano, Francesca Maria Rossi, Antonella Zucchetto, Davide Rossi, Riccardo Bomben, Luca Maurillo, Mariagiovanna Cefalo, Giovanna De Santis, Adriano Venditti, Gianluca Gaidano, Sergio Amadori, Paolo de Fabritiis, Valter Gattei, Giovanni Del Poeta

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article

Abstract

In chronic lymphocytic leukemia the balance between the pro-apoptotic and anti-apoptotic members of the bcl-2 family is involved in the pathogenesis, chemorefractoriness and clinical outcome. Moreover, the recently proposed anti-bcl-2 molecules, such as ABT-199, have emphasized the potential role of of bcl-2 family proteins in the context of target therapies. We investigated bax/bcl-2 ratio by flow cytometry in 502 patients and identified a cut off of 1.50 to correlate bax/bcl-2 ratio with well-established clinical and biological prognosticators. Bax/bcl-2 was 1.50 or over in 263 patients (52%) with chronic lymphocytic leukemia. Higher bax/bcl-2 was associated with low Rai stage, lymphocyte doubling time over 12 months, beta-2 microglobulin less than 2.2 mg/dL, soluble CD23 less than 70 U/mL and a low risk cytogenetic profile (P

Original language	English
Pages (from-to)	77-85
Number of pages	9
Journal	Haematologica
Volume	101
Issue number	1
DOIs	https://doi.org/10.3324/haematol.2015.131854
Publication status	Published - 2016

ASJC Scopus subject areas

Hematology

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Del Principe, M. I., Dal Bo, M., Bittolo, T., Buccisano, F., Rossi, F. M., Zucchetto, A., Rossi, D., Bomben, R., Maurillo, L., Cefalo, M., De Santis, G., Venditti, A., Gaidano, G., Amadori, S., de Fabritiis, P., Gattei, V., & Del Poeta, G. (2016). Clinical significance of bax/bcl-2 ratio in chronic lymphocytic leukemia. Haematologica, 101(1), 77-85. https://doi.org/10.3324/haematol.2015.131854

Clinical significance of bax/bcl-2 ratio in chronic lymphocytic leukemia. / Del Principe, Maria Ilaria; Dal Bo, Michele; Bittolo, Tamara; Buccisano, Francesco; Rossi, Francesca Maria; Zucchetto, Antonella; Rossi, Davide; Bomben, Riccardo; Maurillo, Luca; Cefalo, Mariagiovanna; De Santis, Giovanna; Venditti, Adriano; Gaidano, Gianluca; Amadori, Sergio; de Fabritiis, Paolo; Gattei, Valter; Del Poeta, Giovanni.

In: Haematologica, Vol. 101, No. 1, 2016, p. 77-85.

Research output: Contribution to journal › Article

Del Principe, MI, Dal Bo, M, Bittolo, T, Buccisano, F, Rossi, FM, Zucchetto, A, Rossi, D, Bomben, R, Maurillo, L, Cefalo, M, De Santis, G, Venditti, A, Gaidano, G, Amadori, S, de Fabritiis, P, Gattei, V & Del Poeta, G 2016, 'Clinical significance of bax/bcl-2 ratio in chronic lymphocytic leukemia', Haematologica, vol. 101, no. 1, pp. 77-85. https://doi.org/10.3324/haematol.2015.131854

Del Principe, Maria Ilaria ; Dal Bo, Michele ; Bittolo, Tamara ; Buccisano, Francesco ; Rossi, Francesca Maria ; Zucchetto, Antonella ; Rossi, Davide ; Bomben, Riccardo ; Maurillo, Luca ; Cefalo, Mariagiovanna ; De Santis, Giovanna ; Venditti, Adriano ; Gaidano, Gianluca ; Amadori, Sergio ; de Fabritiis, Paolo ; Gattei, Valter ; Del Poeta, Giovanni. / Clinical significance of bax/bcl-2 ratio in chronic lymphocytic leukemia. In: Haematologica. 2016 ; Vol. 101, No. 1. pp. 77-85.

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abstract = "In chronic lymphocytic leukemia the balance between the pro-apoptotic and anti-apoptotic members of the bcl-2 family is involved in the pathogenesis, chemorefractoriness and clinical outcome. Moreover, the recently proposed anti-bcl-2 molecules, such as ABT-199, have emphasized the potential role of of bcl-2 family proteins in the context of target therapies. We investigated bax/bcl-2 ratio by flow cytometry in 502 patients and identified a cut off of 1.50 to correlate bax/bcl-2 ratio with well-established clinical and biological prognosticators. Bax/bcl-2 was 1.50 or over in 263 patients (52%) with chronic lymphocytic leukemia. Higher bax/bcl-2 was associated with low Rai stage, lymphocyte doubling time over 12 months, beta-2 microglobulin less than 2.2 mg/dL, soluble CD23 less than 70 U/mL and a low risk cytogenetic profile (P",

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AU - De Santis, Giovanna

AU - Venditti, Adriano

AU - Gaidano, Gianluca

AU - Amadori, Sergio

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