Clinical significance of cathepsin D in primary ovarian cancer

G. Scambia, P. B. Panici, G. Ferrandina, G. Salerno, G. D'Agostino, M. Distefano, R. De Vincenzo, A. Ercoli, S. Mancuso

Research output: Contribution to journalArticlepeer-review

Abstract

Cathepsin D (Cath D) levels were assayed in a prospective series of 72 patients with primary ovarian carcinoma, by using an immunoradiometric assay. Cath D levels ranged from 2.00 to 45.60 pmol/mg protein with a median value of 15.80 pmol/mg protein. Cath D levels were higher in metastatic deposits than in primary tumors (median 24.12, range 9.33-98.33 pmol/mg protein versus median 12.76, range 2.00-45.20 pmol/mg protein; P = 0.04). The cut-off levels of the lower, median and upper quartiles of the distribution of Cath D were identified to distinguish patients with low, intermediate, and high Cath D content. Cases with low Cath D content showed a lower percentage of complete response to chemotherapy than cases with intermediate and high Cath D content (22% versus 65% and 47%, respectively) (P = 0.003). Moreover cases with high Cath D content showed a worse prognosis with respect to patients with intermediate Cath D levels (P = 0.09). Interestingly, cases with low Cath D content had a shorter progression-free survival with respect to cases with intermediate Cath D content (P = 0.04). Cath D status retained an independent prognostic value when assessed in the multivariate analysis.

Original languageEnglish
Pages (from-to)935-940
Number of pages6
JournalEuropean Journal of Cancer
Volume30
Issue number7
DOIs
Publication statusPublished - 1994

Keywords

  • cathepsin D
  • ovarian cancer
  • prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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