Clinical significance of cell kinetics in lung cancer

F. Grignani, F. Varoli, A. M. Lavezzi, S. M. Scalambra, C. Vergani, L. Maturri, G. C. Roviaro

Research output: Contribution to journalArticlepeer-review


A series of 24 lung cancer cases was studied: 12 epidermoid carcinomas, 9 adeno-carcinomas, 2 giant cell carcinomas and 1 carcinoid. The patients were staged on the basis of the TNM classification system as 9 stage I, 5 stage II, 9 stage III and 1 stage IV. Using fresh tumour cell samples 2 cell cultures were prepared for each patient: one to identify the percentage of S phase cells (Labelling Index) using the tritiated thymidine method and one for cytogenetic analysis. A genetic map was obtained in 6 cases and revealed no specific numerical or structural alterations. The Labelling Index (L.I.) was calculated for all patients and compared with all TNM parameters. This revealed a certain connection between L.I. and parameters T, S(N) and G but no link with parameters.

Original languageEnglish
Pages (from-to)195-197
Number of pages3
JournalMinerva Medica
Issue number3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Medicine(all)


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