Clinical significance of hyper-IgA in a paediatric laboratory series

Valentina Copetti, Serena Pastore, Carlo De Pieri, Oriano Radillo, Andrea Taddio, Alessandro Ventura, Alberto Tommasini

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The causes of extremely elevated IgA, whether isolated or associated with an increase in other classes of immunoglobulin, are poorly defined in paediatrics. We reviewed the diagnostic significance of very high IgA levels (greater than 3 SD above the mean for age) in a cohort of patients referred to a tertiary care children's hospital. Hyper-IgA was found in 91 of 6364 subjects (1.4%) and in 68 cases was not associated with an increased IgG and/or IgM level. Most subjects with hyper-IgA (73.5%) had a severe immune defect, a chronic rheumatic disease or inflammatory bowel disease, while these conditions were very rare in a control group with normal IgA values (8%). Although our results may in part reflect the experience of a tertiary care centre, we suggest that hyper-IgA in children should always arouse suspicion of a serious disease.

Original languageEnglish
Pages (from-to)1114-1116
Number of pages3
JournalArchives of Disease in Childhood: Education and Practice Edition
Issue number12
Publication statusPublished - Dec 1 2014

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)


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