TY - JOUR
T1 - Clinical significance of hyper-IgA in a paediatric laboratory series
AU - Copetti, Valentina
AU - Pastore, Serena
AU - De Pieri, Carlo
AU - Radillo, Oriano
AU - Taddio, Andrea
AU - Ventura, Alessandro
AU - Tommasini, Alberto
PY - 2014/12/1
Y1 - 2014/12/1
N2 - The causes of extremely elevated IgA, whether isolated or associated with an increase in other classes of immunoglobulin, are poorly defined in paediatrics. We reviewed the diagnostic significance of very high IgA levels (greater than 3 SD above the mean for age) in a cohort of patients referred to a tertiary care children's hospital. Hyper-IgA was found in 91 of 6364 subjects (1.4%) and in 68 cases was not associated with an increased IgG and/or IgM level. Most subjects with hyper-IgA (73.5%) had a severe immune defect, a chronic rheumatic disease or inflammatory bowel disease, while these conditions were very rare in a control group with normal IgA values (8%). Although our results may in part reflect the experience of a tertiary care centre, we suggest that hyper-IgA in children should always arouse suspicion of a serious disease.
AB - The causes of extremely elevated IgA, whether isolated or associated with an increase in other classes of immunoglobulin, are poorly defined in paediatrics. We reviewed the diagnostic significance of very high IgA levels (greater than 3 SD above the mean for age) in a cohort of patients referred to a tertiary care children's hospital. Hyper-IgA was found in 91 of 6364 subjects (1.4%) and in 68 cases was not associated with an increased IgG and/or IgM level. Most subjects with hyper-IgA (73.5%) had a severe immune defect, a chronic rheumatic disease or inflammatory bowel disease, while these conditions were very rare in a control group with normal IgA values (8%). Although our results may in part reflect the experience of a tertiary care centre, we suggest that hyper-IgA in children should always arouse suspicion of a serious disease.
UR - http://www.scopus.com/inward/record.url?scp=84911005332&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84911005332&partnerID=8YFLogxK
U2 - 10.1136/archdischild-2014-306607
DO - 10.1136/archdischild-2014-306607
M3 - Article
C2 - 25053738
AN - SCOPUS:84911005332
VL - 99
SP - 1114
EP - 1116
JO - Archives of Disease in Childhood: Education and Practice Edition
JF - Archives of Disease in Childhood: Education and Practice Edition
SN - 1743-0585
IS - 12
ER -