Clinical significance of the number of oligoclonal bands in patients with clinically isolated syndromes

Gloria Dalla Costa, Gabriella Passerini, Maria Josè Messina, Lucia Moiola, Mariaemma Rodegher, Bruno Colombo, Massimo Locatelli, Giancarlo Comi, Roberto Furlan, Vittorio Martinelli

Research output: Contribution to journalArticle

Abstract

CSF oligoclonal bands (OCBs) in patients with clinically isolated syndromes (CIS) are a risk factor for clinically definite multiple sclerosis (CDMS). We aimed to address the relevance of the number of OCBs in the prognosis of CIS patients. 219 CIS patients were included in the study, and 42% of them developed the disease during follow-up (median: 5.04 years). Patients with a high number of CSF OCBs (third quartile, 8-12 OCBs) had 2.5-fold increase in CDMS risk, while no further increase in the HR of disease was observed for patients with more than 12 OCBs. The results did not change after adjustment for additional correlates of CDMS development. This association may be due to the epitope-spreading phenomenon and may reflect the stage of the disease at the time of the examination.

Original languageEnglish
Pages (from-to)62-67
Number of pages6
JournalJournal of Neuroimmunology
Volume289
DOIs
Publication statusPublished - Dec 15 2015

Keywords

  • Cerebrospinal fluid
  • Multiple sclerosis
  • Oligoclonal bands

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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