Clinical Stability in Human Immunodeficiency Virus-Infected Patients with Community-Acquired Pneumonia

P. Viale, L. Scudeller, N. Petrosillo, E. Girardi, B. Cadeo, L. Signorini, L. Pagani, G. Carosi

Research output: Contribution to journalArticlepeer-review


Clinical stability (CS), defined as normalization of vital signs, is often used to manage inpatients with community-acquired pneumonia (CAP). The main objective of our study was to identify a reliable definition of CS for human immunodeficiency virus (HIV)-positive patients with CAP. During an 18-month period, 437 HIV-positive Italian inpatients with CAP were enrolled in the study. We used 3 definitions of CS (from a less conservative [definition 1] to a more conservative [definition 3] definition) based on combinations of different thresholds for vital signs. Assessments were performed at admission and daily during the hospital stay. For the 3 definitions, 14.9%, 8.0%, and 4.8% of patients were stable at baseline, with deterioration after reaching CS in 7.16%, 4.76%, and 2.05%, respectively. The 8 patients whose conditions deteriorated after reaching CS definition 3 (systolic blood pressure, >90 mm Hg; pulse, 90%; temperature,

Original languageEnglish
Pages (from-to)271-279
Number of pages9
JournalClinical Infectious Diseases
Issue number2
Publication statusPublished - Jan 15 2004

ASJC Scopus subject areas

  • Immunology


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