Clinical status of patients after 10 years of lupus nephritis

G. Moroni, G. Banfi, C. Ponticelli

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Little information is available about the clinical status and outcome of patients with a long history of lupus nephritis. We have reviewed the dossiers of 25 patients (23 women and two men) who have been monitored by our Unit for more than 10 years after the diagnosis of lupus nephritis. At presentation the mean age was 28.5 ± 10.33 (SD) years, the mean plasma creatinine was 136.1 ± 144.7 (SD) nmol/l, the mean proteinuria was 3.02 ± 2.7 (SD) g/day. At initial renal biopsy 18 patients showed diffuse proliferative glomerulonephritis, six patients showed membranous glomerulonephritis and one showed focal proliferative glomerulonephritis. All patients but one were treated with corticosteroids and 18 were also given immunosuppressive agents. At the last observation (16 ± 4.6 (SD) years after presentation), 19 patients have normal plasma creatinine (11 of them show proteinuria less than 0.2 g/day) and six patients show increased plasma creatinine (mean 203.3 ± 61.9 (SD) mmol/l). Eleven patients have been without any treatment for 88 ± 64 (SD) months. The incidence of lupus flare-ups fell significantly after the tenth year (0.31/patient/year between 0 and 10 versus 0.11 between years 11 and 27; p = 0.01). No case of pericarditis or cerebritis occurred after the tenth year. Only one case of cerebral thrombosis occurred before the tenth year, but ten severe atherosclerotic cardiovascular and cerebrovascular complications were seen after the tenth year (two cardiac infarcts, three angina pectoris, four cerebral thrombosis, one cerebral haemorrhage). Two cases of cancer (thyroid and lung) occurred after the tenth year. The professional rehabilitation was good in most patients. These data show that patients with diffuse lupus nephritis may have excellent kidney survival and a good degree of rehabilitation even in the long term. Moreover the activity of the disease seems to quench over the time. However these patients have an increased risk of cardiovascular, cerebrovascular and neoplastic complications.

Original languageEnglish
Pages (from-to)681-689
Number of pages9
JournalQuarterly Journal of Medicine
Volume84
Issue number305
Publication statusPublished - 1992

Fingerprint

Lupus Nephritis
Intracranial Thrombosis
Creatinine
Glomerulonephritis
Proteinuria
Rehabilitation
Kidney
Membranous Glomerulonephritis
Pericarditis
Cerebral Hemorrhage
Angina Pectoris
Immunosuppressive Agents
Thyroid Neoplasms
Lung Neoplasms
Adrenal Cortex Hormones

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clinical status of patients after 10 years of lupus nephritis. / Moroni, G.; Banfi, G.; Ponticelli, C.

In: Quarterly Journal of Medicine, Vol. 84, No. 305, 1992, p. 681-689.

Research output: Contribution to journalArticle

Moroni, G, Banfi, G & Ponticelli, C 1992, 'Clinical status of patients after 10 years of lupus nephritis', Quarterly Journal of Medicine, vol. 84, no. 305, pp. 681-689.
Moroni, G. ; Banfi, G. ; Ponticelli, C. / Clinical status of patients after 10 years of lupus nephritis. In: Quarterly Journal of Medicine. 1992 ; Vol. 84, No. 305. pp. 681-689.
@article{cc4a0a522aae4f0ba7775005a22357a6,
title = "Clinical status of patients after 10 years of lupus nephritis",
abstract = "Little information is available about the clinical status and outcome of patients with a long history of lupus nephritis. We have reviewed the dossiers of 25 patients (23 women and two men) who have been monitored by our Unit for more than 10 years after the diagnosis of lupus nephritis. At presentation the mean age was 28.5 ± 10.33 (SD) years, the mean plasma creatinine was 136.1 ± 144.7 (SD) nmol/l, the mean proteinuria was 3.02 ± 2.7 (SD) g/day. At initial renal biopsy 18 patients showed diffuse proliferative glomerulonephritis, six patients showed membranous glomerulonephritis and one showed focal proliferative glomerulonephritis. All patients but one were treated with corticosteroids and 18 were also given immunosuppressive agents. At the last observation (16 ± 4.6 (SD) years after presentation), 19 patients have normal plasma creatinine (11 of them show proteinuria less than 0.2 g/day) and six patients show increased plasma creatinine (mean 203.3 ± 61.9 (SD) mmol/l). Eleven patients have been without any treatment for 88 ± 64 (SD) months. The incidence of lupus flare-ups fell significantly after the tenth year (0.31/patient/year between 0 and 10 versus 0.11 between years 11 and 27; p = 0.01). No case of pericarditis or cerebritis occurred after the tenth year. Only one case of cerebral thrombosis occurred before the tenth year, but ten severe atherosclerotic cardiovascular and cerebrovascular complications were seen after the tenth year (two cardiac infarcts, three angina pectoris, four cerebral thrombosis, one cerebral haemorrhage). Two cases of cancer (thyroid and lung) occurred after the tenth year. The professional rehabilitation was good in most patients. These data show that patients with diffuse lupus nephritis may have excellent kidney survival and a good degree of rehabilitation even in the long term. Moreover the activity of the disease seems to quench over the time. However these patients have an increased risk of cardiovascular, cerebrovascular and neoplastic complications.",
author = "G. Moroni and G. Banfi and C. Ponticelli",
year = "1992",
language = "English",
volume = "84",
pages = "681--689",
journal = "QJM - Monthly Journal of the Association of Physicians",
issn = "1460-2725",
publisher = "Oxford University Press",
number = "305",

}

TY - JOUR

T1 - Clinical status of patients after 10 years of lupus nephritis

AU - Moroni, G.

AU - Banfi, G.

AU - Ponticelli, C.

PY - 1992

Y1 - 1992

N2 - Little information is available about the clinical status and outcome of patients with a long history of lupus nephritis. We have reviewed the dossiers of 25 patients (23 women and two men) who have been monitored by our Unit for more than 10 years after the diagnosis of lupus nephritis. At presentation the mean age was 28.5 ± 10.33 (SD) years, the mean plasma creatinine was 136.1 ± 144.7 (SD) nmol/l, the mean proteinuria was 3.02 ± 2.7 (SD) g/day. At initial renal biopsy 18 patients showed diffuse proliferative glomerulonephritis, six patients showed membranous glomerulonephritis and one showed focal proliferative glomerulonephritis. All patients but one were treated with corticosteroids and 18 were also given immunosuppressive agents. At the last observation (16 ± 4.6 (SD) years after presentation), 19 patients have normal plasma creatinine (11 of them show proteinuria less than 0.2 g/day) and six patients show increased plasma creatinine (mean 203.3 ± 61.9 (SD) mmol/l). Eleven patients have been without any treatment for 88 ± 64 (SD) months. The incidence of lupus flare-ups fell significantly after the tenth year (0.31/patient/year between 0 and 10 versus 0.11 between years 11 and 27; p = 0.01). No case of pericarditis or cerebritis occurred after the tenth year. Only one case of cerebral thrombosis occurred before the tenth year, but ten severe atherosclerotic cardiovascular and cerebrovascular complications were seen after the tenth year (two cardiac infarcts, three angina pectoris, four cerebral thrombosis, one cerebral haemorrhage). Two cases of cancer (thyroid and lung) occurred after the tenth year. The professional rehabilitation was good in most patients. These data show that patients with diffuse lupus nephritis may have excellent kidney survival and a good degree of rehabilitation even in the long term. Moreover the activity of the disease seems to quench over the time. However these patients have an increased risk of cardiovascular, cerebrovascular and neoplastic complications.

AB - Little information is available about the clinical status and outcome of patients with a long history of lupus nephritis. We have reviewed the dossiers of 25 patients (23 women and two men) who have been monitored by our Unit for more than 10 years after the diagnosis of lupus nephritis. At presentation the mean age was 28.5 ± 10.33 (SD) years, the mean plasma creatinine was 136.1 ± 144.7 (SD) nmol/l, the mean proteinuria was 3.02 ± 2.7 (SD) g/day. At initial renal biopsy 18 patients showed diffuse proliferative glomerulonephritis, six patients showed membranous glomerulonephritis and one showed focal proliferative glomerulonephritis. All patients but one were treated with corticosteroids and 18 were also given immunosuppressive agents. At the last observation (16 ± 4.6 (SD) years after presentation), 19 patients have normal plasma creatinine (11 of them show proteinuria less than 0.2 g/day) and six patients show increased plasma creatinine (mean 203.3 ± 61.9 (SD) mmol/l). Eleven patients have been without any treatment for 88 ± 64 (SD) months. The incidence of lupus flare-ups fell significantly after the tenth year (0.31/patient/year between 0 and 10 versus 0.11 between years 11 and 27; p = 0.01). No case of pericarditis or cerebritis occurred after the tenth year. Only one case of cerebral thrombosis occurred before the tenth year, but ten severe atherosclerotic cardiovascular and cerebrovascular complications were seen after the tenth year (two cardiac infarcts, three angina pectoris, four cerebral thrombosis, one cerebral haemorrhage). Two cases of cancer (thyroid and lung) occurred after the tenth year. The professional rehabilitation was good in most patients. These data show that patients with diffuse lupus nephritis may have excellent kidney survival and a good degree of rehabilitation even in the long term. Moreover the activity of the disease seems to quench over the time. However these patients have an increased risk of cardiovascular, cerebrovascular and neoplastic complications.

UR - http://www.scopus.com/inward/record.url?scp=0026462941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026462941&partnerID=8YFLogxK

M3 - Article

C2 - 1480742

AN - SCOPUS:0026462941

VL - 84

SP - 681

EP - 689

JO - QJM - Monthly Journal of the Association of Physicians

JF - QJM - Monthly Journal of the Association of Physicians

SN - 1460-2725

IS - 305

ER -