TY - JOUR
T1 - Clinical studies in stem cells transplantation for stroke
T2 - A review
AU - Bersano, Anna
AU - Ballabio, Elena
AU - Lanfranconi, Silvia
AU - Boncoraglio, Giorgio B.
AU - Corti, Stefania
AU - Locatelli, Federica
AU - Baron, Pierluigi
AU - Bresolin, Nereo
AU - Parati, Eugenio
AU - Candelise, Livia
PY - 2010/1
Y1 - 2010/1
N2 - Stroke is a significant cause of long-term disability. Currently, once damage from a stroke is established little can be done to recover lost function. Cell transplantation emerged as possible alternative therapy, on the basis of animal studies showing that cells transplanted into the brain not only survive but also lead to functional improvement in different neurodegenerative diseases. Stem cells have been tested in stroke patients as a possible treatment option. While initially stem cells seemed to work by a "cell replacement" mechanism, it is emerging that cell therapy works mostly by providing trophic support to the injured tissue and brain, fostering both neurogenesis and angiogenesis. This review summarizes clinical studies on stem cell transplantation in stroke patients to evaluate the safety, feasibility of administration and tolerability of this experimental treatment. At present there is little evidence to assess the applicability of this treatment in stroke patients and well designed clinical trials are necessary to evaluate safety and toxicity as well as optimal cell type, route and time of delivery.
AB - Stroke is a significant cause of long-term disability. Currently, once damage from a stroke is established little can be done to recover lost function. Cell transplantation emerged as possible alternative therapy, on the basis of animal studies showing that cells transplanted into the brain not only survive but also lead to functional improvement in different neurodegenerative diseases. Stem cells have been tested in stroke patients as a possible treatment option. While initially stem cells seemed to work by a "cell replacement" mechanism, it is emerging that cell therapy works mostly by providing trophic support to the injured tissue and brain, fostering both neurogenesis and angiogenesis. This review summarizes clinical studies on stem cell transplantation in stroke patients to evaluate the safety, feasibility of administration and tolerability of this experimental treatment. At present there is little evidence to assess the applicability of this treatment in stroke patients and well designed clinical trials are necessary to evaluate safety and toxicity as well as optimal cell type, route and time of delivery.
KW - Cell transplantation
KW - Cerebrovascular disease
KW - Clinical studies
KW - Human
KW - Stem cells
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=77649145936&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77649145936&partnerID=8YFLogxK
U2 - 10.2174/157016110790226570
DO - 10.2174/157016110790226570
M3 - Article
C2 - 19485911
AN - SCOPUS:77649145936
VL - 8
SP - 29
EP - 34
JO - Current Vascular Pharmacology
JF - Current Vascular Pharmacology
SN - 1570-1611
IS - 1
ER -