Clinical study protocol for the ARCH project computational modeling for improvement of outcome after vascular access creation

Aron Bode, Anna Caroli, Wouter Huberts, Nils Planken, Luca Antiga, Marielle Bosboom, Andrea Remuzzi, Jan Tordoir

Research output: Contribution to journalArticlepeer-review

Abstract

Despite clinical guidelines and the possibility of diagnostic vascular imaging, creation and maintenance of a vascular access (VA) remains problematic: avoiding short- and long-term VA dysfunction is challenging. Although prognostic factors for VA dysfunction have been identified in previous studies, their potential interplay at a systemic level is disregarded. Consideration of multiple prognostic patient specific factors and their complex interaction using dedicated computational modeling tools might improve outcome after VA creation by enabling a better selection of VA configuration. These computational modeling tools are developed and validated in the ARCH project: a joint initiative of four medical centers and three industrial partners (FP7-ICT-224390). This paper reports the rationale behind computational modeling and presents the clinical study protocol designed for calibrating and validating these modeling tools. The clinical study is based on the pre-operative collection of structural and functional data at a vascular level, as well as a VA functional evaluation during the follow-up period. The strategy adopted to perform the study and for data collection is also described here.

Original languageEnglish
Pages (from-to)369-376
Number of pages8
JournalJournal of Vascular Access
Volume12
Issue number4
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Arteriovenous fistula
  • Clinical protocols
  • Computer simulation
  • Hemodynamics

ASJC Scopus subject areas

  • Surgery
  • Nephrology

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