TY - JOUR
T1 - Clinical target volume definition for glioblastoma radiotherapy planning
T2 - Magnetic resonance imaging and computed tomography
AU - Fiorentino, A.
AU - Caivano, R.
AU - Pedicini, P.
AU - Fusco, V.
PY - 2013/9
Y1 - 2013/9
N2 - Purpose: To assess the differences between the target delineation using computed tomography (CT) and imaging fusion CT/magnetic resonance imaging (MRI) for the radiotherapy planning of glioblastoma. Methods: One hundred-twenty gross tumor volume and clinical target volume on CT and MRI (GTVCT/ CTVCT, GTVMRI/CTVMRI, respectively) were contoured and evaluated. The treatments planning (total dose 60 Gy) based on CTVCT were analysed in terms of percentage of CTVCT and CTVMRI receiving 95 % of the prescribed dose (V95-CTV CT, V95-CTVMRI). Results: GTVs and CTVs contoured on MRI were significantly larger than those delineated on CT (p = 0.0003, p = 0.0006, respectively). Nighty-two percent of CTVCT was coincident with the CTVMRI and 8 % was normal tissue; 20 % of CTVMRI, considered as tumor volume, was not included on CTV CT. The V95-CTVMRI was significantly lower than the V95-CTVCT (p = 0.0005). Conclusions: In the delineation of glioblastoma target volume, fusion CT/MRI was preferred. The CT only is insufficient for the CTV dose coverage.
AB - Purpose: To assess the differences between the target delineation using computed tomography (CT) and imaging fusion CT/magnetic resonance imaging (MRI) for the radiotherapy planning of glioblastoma. Methods: One hundred-twenty gross tumor volume and clinical target volume on CT and MRI (GTVCT/ CTVCT, GTVMRI/CTVMRI, respectively) were contoured and evaluated. The treatments planning (total dose 60 Gy) based on CTVCT were analysed in terms of percentage of CTVCT and CTVMRI receiving 95 % of the prescribed dose (V95-CTV CT, V95-CTVMRI). Results: GTVs and CTVs contoured on MRI were significantly larger than those delineated on CT (p = 0.0003, p = 0.0006, respectively). Nighty-two percent of CTVCT was coincident with the CTVMRI and 8 % was normal tissue; 20 % of CTVMRI, considered as tumor volume, was not included on CTV CT. The V95-CTVMRI was significantly lower than the V95-CTVCT (p = 0.0005). Conclusions: In the delineation of glioblastoma target volume, fusion CT/MRI was preferred. The CT only is insufficient for the CTV dose coverage.
KW - CT
KW - Glioblastoma
KW - Imaging
KW - MRI
KW - Radiotherapy
KW - Target
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U2 - 10.1007/s12094-012-0992-y
DO - 10.1007/s12094-012-0992-y
M3 - Article
C2 - 23359180
AN - SCOPUS:84883282972
VL - 15
SP - 754
EP - 758
JO - Clinical and Translational Oncology
JF - Clinical and Translational Oncology
SN - 1699-048X
IS - 9
ER -