Clinical target volume definition for glioblastoma radiotherapy planning: Magnetic resonance imaging and computed tomography

A. Fiorentino, R. Caivano, P. Pedicini, V. Fusco

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To assess the differences between the target delineation using computed tomography (CT) and imaging fusion CT/magnetic resonance imaging (MRI) for the radiotherapy planning of glioblastoma. Methods: One hundred-twenty gross tumor volume and clinical target volume on CT and MRI (GTVCT/ CTVCT, GTVMRI/CTVMRI, respectively) were contoured and evaluated. The treatments planning (total dose 60 Gy) based on CTVCT were analysed in terms of percentage of CTVCT and CTVMRI receiving 95 % of the prescribed dose (V95-CTV CT, V95-CTVMRI). Results: GTVs and CTVs contoured on MRI were significantly larger than those delineated on CT (p = 0.0003, p = 0.0006, respectively). Nighty-two percent of CTVCT was coincident with the CTVMRI and 8 % was normal tissue; 20 % of CTVMRI, considered as tumor volume, was not included on CTV CT. The V95-CTVMRI was significantly lower than the V95-CTVCT (p = 0.0005). Conclusions: In the delineation of glioblastoma target volume, fusion CT/MRI was preferred. The CT only is insufficient for the CTV dose coverage.

Original languageEnglish
Pages (from-to)754-758
Number of pages5
JournalClinical and Translational Oncology
Volume15
Issue number9
DOIs
Publication statusPublished - Sep 2013

Keywords

  • CT
  • Glioblastoma
  • Imaging
  • MRI
  • Radiotherapy
  • Target

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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