Clinical trials of new antipsychotics: A critical appraisal

C. Barbui, S. Garattini

Research output: Contribution to journalArticlepeer-review


In recent years the efficacy of new antipsychotics has been investigated through a number of randomized controlled trials. This paper considers some methodological flaws that affect these studies and proposes possible solutions. The final goal is the implementation of a new generation of trials with the aim of demonstrating superiority of effect of the new antipsychotic over the reference one.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalInternational Clinical Psychopharmacology
Issue number2
Publication statusPublished - 1999


  • Antipsychotic drugs
  • Randomized controlled trials
  • Schizophrenia
  • Trial methodology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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