Gli inibitori della fosfodiesterasi-5 nella patologia cardiopolmonare: Dai rilievi sperimentali all'applicazione clinica

Translated title of the contribution: Clinical use of phosphodiesterases-5 inhibitors in cardiopulmonary diseases: From experimental evidence to clinical application

Marco Guazzi, Marco Vicenzi, Michele Samaja

Research output: Contribution to journalArticlepeer-review

Abstract

Phosphodiesterases are a class of proteins that primarily modulate intracellular levels of cyclic nucleotides such as cGMP and cAMP. Phosphodiesterase-5 (PDE5) is mainly involved in the smooth muscle cell cGMP inactivation. Chemical inhibition of PDE5 has recently become a valid therapeutic option of nitric oxide pathway potentiation via cell cGMP availability. More specifically, PDE5 inhibition appears successful for the treatment of idiopathic pulmonary arterial hypertension. Additional intriguing therapeutic properties are a protective effect on the myocardium through antihypertrophic and antiapoptotic mechanisms and on vascular function by improving endothelial responsiveness and tolerance to myocardial ischemia-reperfusion injury. These effects imply a potential usefulness in the treatment of coronary artery disease and heart failure. Evidence currently available for considering PDE5 inhibition an additional therapeutic opportunity in cardiovascular disorders is provided.

Translated title of the contributionClinical use of phosphodiesterases-5 inhibitors in cardiopulmonary diseases: From experimental evidence to clinical application
Original languageItalian
Pages (from-to)725-737
Number of pages13
JournalGiornale Italiano di Cardiologia
Volume10
Issue number11-12
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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